Hu Bing, He Xin, Sun Yanxiang, Liu Tong, Li Fei, Feng Li, Huang Yuli
Department of Cardiology, The Eighth Affiliated Hospital, Southern Medical University (The First People's Hospital of Shunde, Foshan), 528300 Foshan, Guangdong, China.
Department of Cardiology, Zhongshan City People's Hospital, 528400 Zhongshan, Guangdong, China.
Rev Cardiovasc Med. 2025 Aug 15;26(8):37415. doi: 10.31083/RCM37415. eCollection 2025 Aug.
The Oxidative Balance Score (OBS) is a new measure for assessing systemic oxidative stress, where higher scores indicate increased exposure to antioxidants. However, the relationship between the OBS and mortality in individuals with hypertension remains unclear.
This study evaluated 8151 hypertensive individuals from the National Health and Nutrition Examination Survey (NHANES) (2001-2018), utilizing data from the National Death Index, tracked through December 31, 2019. The association between OBS and mortality (cardiovascular and all-cause) was examined using multivariable Cox regression models.
During a median follow-up of 9.7 years, which included 1692 deaths (461 of which were cardiovascular), multivariable Cox regression showed the highest quartile of OBS had significantly lower rates of all-cause mortality (hazard ratio (HR) 0.761, 95% CI: 0.635-0.912) and cardiovascular mortality (HR 0.553, 95% CI: 0.388-0.788) compared to those in the lowest quartile. An increase of one unit in the OBS was associated with a 1.9% reduction in all-cause mortality risk and a 3.7% reduction in cardiovascular mortality risk. This relationship remained consistent across various subgroup analyses, and spline regression supported a linear inverse trend.
For adults with hypertension, an elevated OBS is independently associated with a lower risk of mortality both from all-cause and cardiovascular diseases, suggesting that higher antioxidant levels may be protective.
氧化平衡评分（OBS）是一种评估全身氧化应激的新指标，分数越高表明抗氧化剂暴露增加。然而，OBS与高血压患者死亡率之间的关系仍不明确。
本研究评估了来自美国国家健康与营养检查调查（NHANES）（2001 - 2018年）的8151名高血压患者，利用国家死亡指数的数据，追踪至2019年12月31日。使用多变量Cox回归模型检查OBS与死亡率（心血管疾病和全因死亡率）之间的关联。
在中位随访9.7年期间，包括1692例死亡（其中461例为心血管疾病死亡），多变量Cox回归显示，与最低四分位数组相比，OBS最高四分位数组的全因死亡率（风险比（HR）0.761，95%置信区间：0.635 - 0.912）和心血管疾病死亡率（HR 0.553，95%置信区间：0.388 - 0.788）显著更低。OBS每增加一个单位，全因死亡风险降低1.9%，心血管疾病死亡风险降低3.7%。在各种亚组分析中，这种关系保持一致，样条回归支持线性反比趋势。
对于患有高血压的成年人，较高的OBS与较低的全因和心血管疾病死亡风险独立相关，这表明较高的抗氧化剂水平可能具有保护作用。
