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Disease severity and minimal clinically important differences in clinical outcome assessments for Alzheimer's disease clinical trials.

作者信息

Van Dyck Christopher H, O'Dell Ryan S, Mecca Adam P

机构信息

Department of Psychiatry Alzheimer's Disease Research Unit, Yale School of Medicine New Haven Connecticut USA.

出版信息

Alzheimers Dement (N Y). 2023 May 11;9(2):e12388. doi: 10.1002/trc2.12388. eCollection 2023 Apr-Jun.

DOI:10.1002/trc2.12388
PMID:37187779
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10175943/
Abstract
摘要

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本文引用的文献

1
Expectations and clinical meaningfulness of randomized controlled trials.随机对照试验的预期和临床意义。
Alzheimers Dement. 2023 Jun;19(6):2730-2736. doi: 10.1002/alz.12959. Epub 2023 Feb 7.
2
Lecanemab for Alzheimer's disease.用于治疗阿尔茨海默病的lecanemab
BMJ. 2022 Dec 19;379:o3010. doi: 10.1136/bmj.o3010.
3
Lecanemab in Early Alzheimer's Disease.早期阿尔茨海默病中的lecanemab
N Engl J Med. 2023 Jan 5;388(1):9-21. doi: 10.1056/NEJMoa2212948. Epub 2022 Nov 29.
4
The need to show minimum clinically important differences in Alzheimer's disease trials.在阿尔茨海默病临床试验中需要显示最小临床重要差异。
Lancet Psychiatry. 2021 Nov;8(11):1013-1016. doi: 10.1016/S2215-0366(21)00197-8. Epub 2021 Jun 1.
5
Disease severity and minimal clinically important differences in clinical outcome assessments for Alzheimer's disease clinical trials.阿尔茨海默病临床试验临床结局评估中的疾病严重程度及最小临床重要差异
Alzheimers Dement (N Y). 2019 Aug 2;5:354-363. doi: 10.1016/j.trci.2019.06.005. eCollection 2019.
6
Bridging the gap: using triangulation methodology to estimate minimal clinically important differences (MCIDs).弥合差距：运用三角测量法估算最小临床重要差异（MCIDs）。
COPD. 2005 Mar;2(1):157-65. doi: 10.1081/copd-200050508.