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右心室衰竭:当前策略与未来发展

Right ventricular failure: Current strategies and future development.

作者信息

Monteagudo-Vela María, Tindale Alexander, Monguió-Santín Emilio, Reyes-Copa Guillermo, Panoulas Vasileios

机构信息

Cardiothoracic Surgery Department, Hospital Universitario de la Princesa, Madrid, Spain.

Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, Royal Brompton and Harefield Hospitals, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.

出版信息

Front Cardiovasc Med. 2023 Apr 28;10:998382. doi: 10.3389/fcvm.2023.998382. eCollection 2023.

Abstract

Right heart failure can be defined as a clinical syndrome consisting of signs and symptoms of heart failure resulting from right ventricular dysfunction. Function is normally altered due to three mechanisms: (1) pressure overload (2) volume overload, or (3) a decrease in contractility due to ischaemia, cardiomyopathy or arrythmias. Diagnosis is based upon a combination of clinical assessment plus echocardiographic, laboratory and haemodynamic parameters, and clinical risk assessment. Treatment includes medical management, mechanical assist devices and transplantation if recovery is not observed. Distinct attention to special circumstances such as left ventricular assist device implantation should be sought. The future is moving towards new therapies, both pharmacological and device centered. Immediate diagnosis and management of RV failure, including mechanical circulatory support where needed, alongside a protocolized approach to weaning is important in successfully managing right ventricular failure.

摘要

右心衰竭可定义为一种临床综合征,由右心室功能障碍导致的心力衰竭体征和症状组成。通常由于三种机制导致功能改变:(1)压力负荷过重;(2)容量负荷过重;或(3)由于缺血、心肌病或心律失常导致的收缩力下降。诊断基于临床评估、超声心动图、实验室和血流动力学参数以及临床风险评估的综合结果。治疗包括药物治疗、机械辅助装置治疗,若未观察到恢复则进行移植治疗。应特别关注特殊情况,如左心室辅助装置植入。未来正朝着以药物和装置为中心的新疗法发展。对右心衰竭进行即时诊断和管理,包括在需要时进行机械循环支持,以及采用规范化的撤机方法,对于成功管理右心室衰竭至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eba9/10175590/c45b678b40d1/fcvm-10-998382-g001.jpg

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