Aggarwal Piyush, Anwariya Anupriya, Kavanal Anwin Joseph, Sood Ashwani, Jena Santosh Ranjan, Mittal Bhagwant Rai
Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012 India.
Nucl Med Mol Imaging. 2023 Jun;57(3):159-161. doi: 10.1007/s13139-023-00789-3. Epub 2023 Feb 18.
Peptide receptor radionuclide therapy (PRRT) has become an established treatment for patients with inoperable and/or metastatic, well-differentiated neuroendocrine tumors with overexpression of somatostatin receptor type 2 (SSTR-2). The post-therapy Lu-DOTATATE whole-body scan not only assesses the biodistribution of the lesions seen on pre-therapy Ga-SSTR PET/CT scan but also provides a quick assessment of disease status and dosimetry during treatment. Like any other radionuclide scan, the whole-body Lu-DOTATATE scan may also show abnormal radiotracer uptake, which may require further imaging to establish its exact etiology. Though radiotracer emboli mimicking focal pulmonary lesions have been described with F-FDG and Ga-DOTANOC PET/CT scans, similar artifacts with post-therapy Lu-DOTATATE scans have not been described. Herein, we report two cases of hot emboli in the post-therapy Lu-DOTATATE scans.
肽受体放射性核素治疗（PRRT）已成为无法手术切除和/或发生转移、分化良好且2型生长抑素受体（SSTR-2）过表达的神经内分泌肿瘤患者的既定治疗方法。治疗后的镥[¹⁷⁷Lu] DOTATATE全身扫描不仅可评估治疗前镓[⁶⁸Ga] -SSTR PET/CT扫描中所见病变的生物分布，还能在治疗期间快速评估疾病状态和剂量测定。与任何其他放射性核素扫描一样，全身镥[¹⁷⁷Lu] DOTATATE扫描也可能显示放射性示踪剂摄取异常，这可能需要进一步成像以确定其确切病因。尽管在氟代脱氧葡萄糖[¹⁸F-FDG]和镓[⁶⁸Ga] -DOTANOC PET/CT扫描中已描述过类似局灶性肺部病变的放射性示踪剂栓子，但治疗后镥[¹⁷⁷Lu] DOTATATE扫描的类似伪影尚未见报道。在此，我们报告两例治疗后镥[¹⁷⁷Lu] DOTATATE扫描出现热栓子的病例。
