磷酸氯喹凝胶治疗低危型人乳头瘤病毒引起的尖锐湿疣
Treatment of condylomata acuminata caused by low-risk human papillomavirus with chloroquine phosphate gel.
作者信息
Li Xiangling, Guan Zhisheng, Liu Qi, Yang Wei, Huang Jie, Yuan Manli, Yu Junlong
机构信息
Key Laboratory of Basic Research of Traditional Chinese Medicine, Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi, China.
Guangzhou Hybribio Biotechnology Technology Co., Ltd., Guangzhou, Guangdong, China.
出版信息
Front Med (Lausanne). 2023 Apr 28;10:1171550. doi: 10.3389/fmed.2023.1171550. eCollection 2023.
OBJECTIVE
To observe the stability and therapeutic effect of chloroquine phosphate gel on human condylomata acuminata (CA) caused by low-risk human papillomavirus (HPV).
METHODS
The appearance, viscosity, pH, chloroquine concentration, deethylchloroquine concentration and content uniformity of chloroquine phosphate gel were examined for 24 months, the gel met the quality standards throughout the 24-month observation. A nude mouse model harboring CA xenografts was used to observe the therapeutic effect of this gel on CA .
RESULTS
After 14 days of gel administration, compared with the control group, the treatment group had significantly smaller warts and significantly reduced DNA copy numbers of HPV6 and HPV11 in the wart tissues. Immunohistochemistry analysis of p53 protein expression in the wart tissues of the treatment group was significantly increased.
CONCLUSION
Chloroquine phosphate gel was stable and effective against CA, possibly through the promotion of p53 protein expression to induce apoptosis, leading to the involution of warts.
目的
观察磷酸氯喹凝胶对低危型人乳头瘤病毒（HPV）所致的尖锐湿疣（CA）的稳定性及治疗效果。
方法
对磷酸氯喹凝胶的外观、黏度、pH值、氯喹浓度、去乙基氯喹浓度及含量均匀度进行24个月的检测，该凝胶在24个月的观察期内均符合质量标准。采用携带CA异种移植物的裸鼠模型观察该凝胶对CA的治疗效果。
结果
凝胶给药14天后，与对照组相比，治疗组疣体明显变小，疣体组织中HPV6和HPV11的DNA拷贝数显著降低。治疗组疣体组织中p53蛋白表达的免疫组化分析显著增加。
结论
磷酸氯喹凝胶对CA稳定且有效，可能是通过促进p53蛋白表达诱导凋亡，从而导致疣体消退。
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