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Disseminated tuberculosis involving the eye, skin, axillary lymph nodes and lungs in an immunocompetent host.免疫功能正常宿主发生的播散性结核病,累及眼部、皮肤、腋窝淋巴结和肺部。
BMJ Case Rep. 2023 May 15;16(5):e254392. doi: 10.1136/bcr-2022-254392.
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本文引用的文献

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Endogenous Tuberculous Endophthalmitis and Panophthalmitis: A Systematic Review of Case Reports and Case Series.内源性结核性眼内炎和全眼球炎:病例报告和病例系列的系统评价
Clin Ophthalmol. 2020 Oct 7;14:3075-3096. doi: 10.2147/OPTH.S265521. eCollection 2020.
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The Immune Escape Mechanisms of .的免疫逃逸机制。
Int J Mol Sci. 2019 Jan 15;20(2):340. doi: 10.3390/ijms20020340.
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Tuberculous Uveitis Presenting with a Bullous Exudative Retinal Detachment: A Case Report and Systematic Literature Review.结核性虹膜炎伴大疱性渗出性视网膜脱离:病例报告及系统文献回顾。
Ocul Immunol Inflamm. 2019;27(6):998-1009. doi: 10.1080/09273948.2018.1485958. Epub 2018 Jul 3.
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Index-TB guidelines: Guidelines on extrapulmonary tuberculosis for India.索引-TB 指南:印度肺外结核指南。
Indian J Med Res. 2017 Apr;145(4):448-463. doi: 10.4103/ijmr.IJMR_1950_16.
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Cutaneous Squamous Cell Carcinoma in Lupus Vulgaris Caused by Drug Resistant .寻常狼疮中由耐药引起的皮肤鳞状细胞癌
Indian Dermatol Online J. 2017 Jul-Aug;8(4):257-260. doi: 10.4103/2229-5178.209604.
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Cutaneous Tuberculosis.皮肤结核病。
Microbiol Spectr. 2017 Jan;5(1). doi: 10.1128/microbiolspec.TNMI7-0010-2016.
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Cutaneous tuberculosis overview and current treatment regimens.皮肤结核概述及当前治疗方案
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Inhibition of Autophagy by MiR-30A Induced by Mycobacteria tuberculosis as a Possible Mechanism of Immune Escape in Human Macrophages.结核分枝杆菌诱导的MiR-30A对自噬的抑制作用可能是人类巨噬细胞免疫逃逸的一种机制。
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Novel role of Wag31 in protection of mycobacteria under oxidative stress.Wag31在氧化应激下对分枝杆菌的保护作用中的新角色。
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Clinical features and predictors of a complicated treatment course in peripheral tuberculous lymphadenitis.
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免疫功能正常宿主发生的播散性结核病,累及眼部、皮肤、腋窝淋巴结和肺部。

Disseminated tuberculosis involving the eye, skin, axillary lymph nodes and lungs in an immunocompetent host.

作者信息

Haque Obaid Imtiyazul, Rizvi Syed Asghar, Siddiqui Ziya

机构信息

Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA

Jawaharlal Nehru Medical College and Hospital, Aligarh, Uttar Pradesh, India.

出版信息

BMJ Case Rep. 2023 May 15;16(5):e254392. doi: 10.1136/bcr-2022-254392.

DOI:10.1136/bcr-2022-254392
PMID:37188489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10186401/
Abstract

A female in her early 40s presented to the outpatient clinic for weight loss, fatigue, cough, followed by a gradual painful loss of vision in the right eye associated with redness over the past 3 months. Physical examination revealed bilateral axillary lymphadenopathy and non-healing skin ulcers on the left forearm and the left gluteal region. The patient had no light perception in the right eye and grade 4+ cells in the anterior chamber. A chest X-ray showed a cavitary lesion in the left upper lobe. Histopathological tests from the skin and lymph nodes revealed caseating granulomas, raising the suspicion of tuberculosis. A sputum nucleic acid amplification test was performed, which returned positive for The patient was treated with antitubercular chemotherapy and showed encouraging signs of progress after the treatment.

摘要

一名40岁出头的女性因体重减轻、疲劳、咳嗽前往门诊就诊,随后在过去3个月中右眼逐渐出现疼痛性视力丧失并伴有眼红。体格检查发现双侧腋窝淋巴结肿大,左前臂和左臀部有不愈合的皮肤溃疡。患者右眼无光感,前房有4+级细胞。胸部X线显示左上叶有空洞性病变。皮肤和淋巴结的组织病理学检查显示干酪样肉芽肿,怀疑为结核病。进行了痰核酸扩增试验,结果呈阳性。患者接受了抗结核化疗,治疗后显示出令人鼓舞的进展迹象。