人胎盘刷状缘膜囊泡中的硫酸盐转运：硒酸盐的竞争性抑制作用

Sulphate transport in human placental brush-border membrane vesicles: competitive inhibition by selenate.

作者信息

Shennan D B, Boyd C A

出版信息

Biochim Biophys Acta. 1986 Jul 10;859(1):122-4. doi: 10.1016/0005-2736(86)90326-3.

Abstract

The effect of selenate on sulphate uptake by human placental brush-border membrane vesicles has been investigated. Selenate added to the incubation medium inhibits 1 mM sulphate uptake in a dose-dependent fashion with a Ki of approx. 2.5 mM. The inhibition by selenate is competitive, suggesting that selenate and sulphate share a common transporter (an anion exchange system) which may be of particular importance for the transport of such essential trace elements to the fetus.

摘要

研究了硒酸盐对人胎盘刷状缘膜囊泡摄取硫酸盐的影响。添加到孵育培养基中的硒酸盐以剂量依赖性方式抑制1 mM硫酸盐的摄取，其抑制常数（Ki）约为2.5 mM。硒酸盐的抑制作用具有竞争性，这表明硒酸盐和硫酸盐共用一种共同的转运体（一种阴离子交换系统），这对于将此类必需微量元素转运至胎儿可能尤为重要。