Shennan D B, Russell T V
Hannah Research Institute, Ayr, U.K.
Biochem Pharmacol. 1991 Mar 1;41(5):723-8. doi: 10.1016/0006-2952(91)90072-d.
The effect of salicylate on sulphate transport by the human placenta has been studied using isolated brush-border membrane vesicles and placental tissue slices. Sulphate uptake by isolated vesicles was inhibited in a dose dependent fashion (K1 approximately 3 mM) by salicylate. It appears that this drug blocks sulphate accumulation in a non-competitive manner. Sulphate efflux from preloaded vesicles was also found to be markedly reduced by salicylate in a non-competitive fashion. Consistent with the vesicle studies salicylate inhibited sulphate transport by placental tissue slices. The results suggest that salicylate ingestion could compromise feto-placental sulphate homeostasis. In addition we have found that the aspirin-like drug, flufenamic acid, inhibits sulphate transport by isolated microvillus membrane vesicles.
利用分离的刷状缘膜囊泡和胎盘组织切片，研究了水杨酸盐对人胎盘硫酸盐转运的影响。水杨酸盐以剂量依赖性方式（K1约为3 mM）抑制分离囊泡对硫酸盐的摄取。看来这种药物以非竞争性方式阻断硫酸盐的积累。还发现水杨酸盐以非竞争性方式显著降低预加载囊泡中硫酸盐的外排。与囊泡研究一致，水杨酸盐抑制胎盘组织切片的硫酸盐转运。结果表明，摄入水杨酸盐可能会损害胎儿-胎盘硫酸盐稳态。此外，我们发现阿司匹林样药物氟芬那酸可抑制分离的微绒毛膜囊泡的硫酸盐转运。
