Hasamoh Yusuf, Thadanipon Kunlawat, Juntongjin Premjit
Division of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand.
Department of Clinical Epidemiology and Biostatistics, and Division of Dermatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Dermatology. 2022;238(3):404-411. doi: 10.1159/000517514. Epub 2021 Aug 4.
Vitamin D deficiency is frequently associated with several medical conditions. However, a comprehensive meta-analysis assessing the association between vitamin D level and acne is lacking.
To determine the relationship between vitamin D level and acne, and to assess the association between vitamin D level and acne severity.
This meta-analysis was assessed by using the PubMed, EMBASE, Cochrane, and Scopus databases following the PRISMA guidelines. Serum/plasma 25-hydroxyvitamin D (25[OH]D) level, vitamin D deficiency, and the severity association between acne patients and healthy controls (HCs) were evaluated. The quality assessment was performed by using the Newcastle-Ottawa Scale.
Thirteen articles with a total of 1,362 acne patients and 1,081 HCs were included. The circulating 25(OH)D levels were significantly lower in patients with acne than in HCs (pooled MD = -9.02 ng/mL, 95% CI = -13.22 to -4.81, p < 0.0001). Vitamin D deficiency was more prevalent in acne patients than in HCs (pooled OR = 2.97, 95% CI = 1.68-5.23, I2 = 72%). Also, vitamin D levels were negatively correlated with acne severity.
This meta-analysis demonstrated the significantly low vitamin D levels in acne patients. Also, there was evidence of an inverse association between vitamin D levels and acne severity. Therefore, vitamin D might be involved in the pathogenesis of acne.
维生素D缺乏常与多种疾病相关。然而，目前缺乏一项全面的荟萃分析来评估维生素D水平与痤疮之间的关联。
确定维生素D水平与痤疮之间的关系，并评估维生素D水平与痤疮严重程度之间的关联。
本荟萃分析按照PRISMA指南，通过检索PubMed、EMBASE、Cochrane和Scopus数据库进行评估。评估了血清/血浆25-羟基维生素D（25[OH]D）水平、维生素D缺乏情况，以及痤疮患者与健康对照者（HCs）之间的严重程度关联。使用纽卡斯尔-渥太华量表进行质量评估。
纳入了13篇文章，共1362例痤疮患者和1081例健康对照者。痤疮患者的循环25(OH)D水平显著低于健康对照者（合并MD = -9.02 ng/mL，95%CI = -13.22至-4.81，p < 0.0001）。痤疮患者中维生素D缺乏比健康对照者更普遍（合并OR = 2.97，95%CI = 1.68 - 5.23，I2 = 72%）。此外，维生素D水平与痤疮严重程度呈负相关。
这项荟萃分析表明痤疮患者的维生素D水平显著较低。而且，有证据表明维生素D水平与痤疮严重程度之间存在负相关。因此，维生素D可能参与了痤疮的发病机制。
