• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

NCAP 家族基因与人类肉瘤预后和免疫浸润的关联。

Association of NCAP family genes with prognosis and immune infiltration of human sarcoma.

机构信息

Department of Orthopedics, People’s Hospital of Pingchang County, Pingchang, Sichuan 636400, China.

Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.

出版信息

Aging (Albany NY). 2023 May 9;15(10):4108-4121. doi: 10.18632/aging.204683.

DOI:10.18632/aging.204683
PMID:37192046
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10258000/
Abstract

OBJECTIVE

This study was conducted to explore the correlation of NCAP family genes with expression, prognosis, and immune infiltration in human sarcoma.

RESULTS

Compared with normal human tissues, six NCAP family genes were highly expressed in sarcoma tissues, and high expression of the six genes were significantly associated with the poor prognosis of sarcoma patients. The expression of NCAPs in sarcoma was significantly related to the low infiltration level of macrophages and CD4+ T cells. GO and KEGG enrichment analysis showed that NCAPs and their interacting genes were mainly enriched in organelle fission for biological processes (BP), spindle for cellular component (CC), tubulin binding for molecular function (MF), and 'Cell cycle' pathway.

METHODS

We explored the expression of NCAP family members by ONCOMINE, and GEPIA databases. Additionally, the prognostic value of NCAP family genes in sarcoma was detected by Kaplan-Meier Plotter and GEPIA databases. Moreover, we explored the relationship between NCAP family gene expression level and immune infiltration using the TIMER database. Finally, we performed GO and KEGG analysis for NCAPs-related genes by DAVID database.

CONCLUSION

The six members of NCAP gene family can be used as biomarkers to predict the prognosis of sarcoma. They were also correlated with the low immune infiltration in sarcoma.

摘要

目的

本研究旨在探讨 NCAP 家族基因与人类肉瘤表达、预后和免疫浸润的相关性。

结果

与正常人体组织相比，NCAP 家族的 6 个基因在肉瘤组织中高表达，且这 6 个基因的高表达与肉瘤患者的不良预后显著相关。肉瘤中 NCAPs 的表达与巨噬细胞和 CD4+T 细胞浸润水平低显著相关。GO 和 KEGG 富集分析显示，NCAPs 及其相互作用基因主要富集于生物学过程（BP）中的细胞器分裂、细胞成分（CC）中的纺锤体、分子功能（MF）中的微管结合以及“细胞周期”通路。

方法

我们通过 ONCOMINE 和 GEPIA 数据库探索 NCAP 家族成员的表达情况。此外，我们通过 Kaplan-Meier Plotter 和 GEPIA 数据库检测 NCAP 家族基因在肉瘤中的预后价值。并且，我们使用 TIMER 数据库探索 NCAP 家族基因表达水平与免疫浸润之间的关系。最后，我们通过 DAVID 数据库对 NCAP 相关基因进行 GO 和 KEGG 分析。

结论

NCAP 基因家族的 6 个成员可作为预测肉瘤预后的生物标志物，它们与肉瘤中免疫浸润程度低有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f004/10258000/bc928ddf20b0/aging-15-204683-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f004/10258000/752b0551bd47/aging-15-204683-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f004/10258000/021c5ac4ee12/aging-15-204683-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f004/10258000/35c206d59739/aging-15-204683-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f004/10258000/21b63709066f/aging-15-204683-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f004/10258000/c18e1e03cdd3/aging-15-204683-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f004/10258000/06f50efab57e/aging-15-204683-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f004/10258000/bc928ddf20b0/aging-15-204683-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f004/10258000/752b0551bd47/aging-15-204683-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f004/10258000/021c5ac4ee12/aging-15-204683-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f004/10258000/35c206d59739/aging-15-204683-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f004/10258000/21b63709066f/aging-15-204683-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f004/10258000/c18e1e03cdd3/aging-15-204683-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f004/10258000/06f50efab57e/aging-15-204683-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f004/10258000/bc928ddf20b0/aging-15-204683-g007.jpg

相似文献

1
Association of NCAP family genes with prognosis and immune infiltration of human sarcoma.NCAP 家族基因与人类肉瘤预后和免疫浸润的关联。
Aging (Albany NY). 2023 May 9;15(10):4108-4121. doi: 10.18632/aging.204683.
2
Combined analysis of expression, prognosis and immune infiltration of GINS family genes in human sarcoma.人类肉瘤中 GINS 家族基因的表达、预后和免疫浸润的综合分析。
Aging (Albany NY). 2022 Jul 27;14(14):5895-5907. doi: 10.18632/aging.204191.
3
Integrative analysis of expression, prognostic significance and immune infiltration of RFC family genes in human sarcoma.RFC 家族基因在人类肉瘤中的表达、预后意义及免疫浸润的综合分析。
Aging (Albany NY). 2022 Apr 29;14(8):3705-3719. doi: 10.18632/aging.204039.
4
Prognosis and Immune Infiltration of Chromobox Family Genes in Sarcoma.肉瘤中染色体框家族基因的预后与免疫浸润
Front Oncol. 2021 May 11;11:657595. doi: 10.3389/fonc.2021.657595. eCollection 2021.
5
Prognostic value of p16, p53, and pcna in sarcoma and an evaluation of immune infiltration.p16、p53 和 pcna 在肉瘤中的预后价值及免疫浸润的评价。
J Orthop Surg Res. 2022 Jun 10;17(1):305. doi: 10.1186/s13018-022-03193-3.
6
UHRF1 Could Be a Prognostic Biomarker and Correlated with Immune Cell Infiltration in Hepatocellular Carcinoma.UHRF1可能是一种预后生物标志物，且与肝细胞癌中的免疫细胞浸润相关。
Int J Gen Med. 2021 Oct 13;14:6769-6776. doi: 10.2147/IJGM.S335016. eCollection 2021.
7
CMA1 is potent prognostic marker and associates with immune infiltration in gastric cancer.CMA1 是一种强有力的预后标志物，并与胃癌的免疫浸润相关。
Autoimmunity. 2020 Jun;53(4):210-217. doi: 10.1080/08916934.2020.1735371. Epub 2020 Mar 4.
8
Six Cell Cycle-related Genes Serve as Potential Prognostic Biomarkers and Correlated with Immune Infiltrates in Hepatocellular Carcinoma.六个细胞周期相关基因作为潜在的预后生物标志物，并与肝细胞癌中的免疫浸润相关。
J Cancer. 2023 Jan 1;14(1):9-23. doi: 10.7150/jca.76809. eCollection 2023.
9
Heat Shock Protein 90 Family Isoforms as Prognostic Biomarkers and Their Correlations with Immune Infiltration in Breast Cancer.热休克蛋白 90 家族亚型作为预后生物标志物及其与乳腺癌免疫浸润的相关性。
Biomed Res Int. 2020 Oct 21;2020:2148253. doi: 10.1155/2020/2148253. eCollection 2020.
10
Association of with prognosis and immune infiltration of sarcoma.与肉瘤预后和免疫浸润的关联。
Aging (Albany NY). 2023 Jan 30;15(2):567-582. doi: 10.18632/aging.204503.

本文引用的文献

1
NCAPD2 promotes breast cancer progression through E2F1 transcriptional regulation of CDK1.NCAPD2 通过 E2F1 对 CDK1 的转录调控促进乳腺癌进展。
Cancer Sci. 2023 Mar;114(3):896-907. doi: 10.1111/cas.15347. Epub 2022 Dec 25.
2
NCAPG promotes the oncogenesis and progression of non-small cell lung cancer cells through upregulating LGALS1 expression.NCAPG 通过上调 LGALS1 表达促进非小细胞肺癌细胞的发生和进展。
Mol Cancer. 2022 Feb 18;21(1):55. doi: 10.1186/s12943-022-01533-9.
3
Construction of a Prognosis-Related Gene Signature by Weighted Gene Coexpression Network Analysis in Ewing Sarcoma.
基于加权基因共表达网络分析构建尤因肉瘤预后相关基因签名。
Comput Math Methods Med. 2022 Jan 27;2022:8798624. doi: 10.1155/2022/8798624. eCollection 2022.
4
Non-SMC condensin I complex subunit H (NCAPH), a regulator of cell cycle, predicts poor prognosis in lung adenocarcinoma patients: a study mainly based on TCGA and GEO database.非SMC凝聚素I复合体亚基H（NCAPH）作为一种细胞周期调节因子，可预测肺腺癌患者的不良预后：一项主要基于TCGA和GEO数据库的研究
Transl Cancer Res. 2020 Dec;9(12):7572-7587. doi: 10.21037/tcr-20-2217.
5
NCAPD3 promotes prostate cancer progression by up-regulating EZH2 and MALAT1 through STAT3 and E2F1.NCAPD3 通过 STAT3 和 E2F1 上调 EZH2 和 MALAT1 促进前列腺癌进展。
Cell Signal. 2022 Apr;92:110265. doi: 10.1016/j.cellsig.2022.110265. Epub 2022 Jan 24.
6
NCAPG promotes the progression of lung adenocarcinoma via the TGF-β signaling pathway.NCAPG通过TGF-β信号通路促进肺腺癌的进展。
Cancer Cell Int. 2021 Aug 21;21(1):443. doi: 10.1186/s12935-021-02138-w.
7
NCAPD2 inhibits autophagy by regulating Ca/CAMKK2/AMPK/mTORC1 pathway and PARP-1/SIRT1 axis to promote colorectal cancer.NCAPD2 通过调节 Ca/CAMKK2/AMPK/mTORC1 通路和 PARP-1/SIRT1 轴抑制自噬，从而促进结直肠癌。
Cancer Lett. 2021 Nov 1;520:26-37. doi: 10.1016/j.canlet.2021.06.029. Epub 2021 Jul 3.
8
Targeting cell-cycle machinery in cancer.针对癌症中的细胞周期机制。
Cancer Cell. 2021 Jun 14;39(6):759-778. doi: 10.1016/j.ccell.2021.03.010. Epub 2021 Apr 22.
9
Osteosarcoma: a review of current and future therapeutic approaches.骨肉瘤：当前和未来治疗方法的综述。
Biomed Eng Online. 2021 Mar 2;20(1):24. doi: 10.1186/s12938-021-00860-0.
10
Future Directions in the Treatment of Osteosarcoma.骨肉瘤治疗的未来方向。
Cells. 2021 Jan 15;10(1):172. doi: 10.3390/cells10010172.