National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu 610064, Sichuan, P. R. China.
Department of Gastroenterology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, Sichuan, P. R. China.
J Mater Chem B. 2023 Jun 7;11(22):4934-4945. doi: 10.1039/d3tb00099k.
Wound management is highly clinically desirable due to the complexity and diversity of the wound repair process. However, it is still a major clinical challenge to develop a wound dressing with the capabilities of real-time and remote monitoring during wound healing. Herein, we have designed a polymer-based wound dressing in the form of a conductive, soft, temperature-responsive, antibacterial and biocompatible hydrogel, which is composed of polyacrylic acid (PAA)-grafted poly(-isopropylacrylamide) (PNIPAM), vinyl-based polyacrylamide (PAM) and silver nanowires (AgNWs). In this hydrogel dressing, PAA-grafted PNIPAM acts as conformal interface and intrinsic temperature-responsive matrix, PAM helps to construct semi-penetrating polymer networks (SIPNs) to improve the mechanical properties, while the AgNWs introduce a three-dimensional conductive hydrogel network with antibacterial properties and sensing properties. The constructed hydrogel matrix was connected to a Bluetooth module to transmit the temperature changes wirelessly to a smart device. The design integrating a conductive hydrogel dressing with a wireless transmission module realized the real-time and wireless monitoring of the wound temperature, which is helpful to provide an early diagnosis of infection. This proof-of-concept study is highly promising in the development of new strategies to significantly improve wound management and other pathological diagnostics or treatments.
由于伤口修复过程的复杂性和多样性，伤口管理在临床上非常需要。然而，开发一种在伤口愈合过程中具有实时和远程监测功能的伤口敷料仍然是一个主要的临床挑战。在此，我们设计了一种基于聚合物的伤口敷料，其形式为具有导电性、柔软、温度响应性、抗菌和生物相容性的水凝胶，由接枝聚丙烯酸（PAA）的聚（N-异丙基丙烯酰胺）（PNIPAM）、基于乙烯的聚丙烯酰胺（PAM）和银纳米线（AgNWs）组成。在这种水凝胶敷料中，接枝的 PAA-g-PNIPAM 作为顺应性界面和固有温度响应基质，PAM 有助于构建半互穿聚合物网络（SIPN）以提高机械性能，而 AgNWs 则引入了具有抗菌性能和传感性能的三维导电水凝胶网络。所构建的水凝胶基质与蓝牙模块相连，可将温度变化无线传输到智能设备上。这种具有无线传输模块的导电水凝胶敷料的设计实现了伤口温度的实时无线监测，有助于提供感染的早期诊断。这项概念验证研究在开发新策略方面具有很大的前景，可以显著改善伤口管理和其他病理诊断或治疗。
