Berger M R, Petru E, Habs M, Schmähl D
Cancer Lett. 1986 Jun;31(3):311-8. doi: 10.1016/0304-3835(86)90153-9.
The administration of N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide FANFT) by gavage to female NMRI-mice resulted in a high incidence of neoplasms of the forestomach. From 117 effective animals which were pooled from 3 dosed groups, 30 squamous cell carcinomas and 26/117 papillomas of the forestomach were diagnosed. Only 5/117 neoplasms of the urinary bladder occurred. The average cumulative dose administered was 1180 mg/mouse, and the mean latent period for the induction of forestomach tumours was 574 days. The mode of application seems to be an important factor in the carcinogenicity of FANFT.
通过灌胃法给雌性NMRI小鼠施用N-[4-(5-硝基-2-呋喃基)-2-噻唑基]-甲酰胺（FANFT）会导致前胃肿瘤的高发病率。从3个给药组汇总的117只有效动物中，诊断出30例前胃鳞状细胞癌和26/117例前胃乳头状瘤。仅发生了5/117例膀胱肿瘤。平均累积给药剂量为1180毫克/小鼠，前胃肿瘤诱导的平均潜伏期为574天。施用方式似乎是FANFT致癌性的一个重要因素。
