Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
Cell Rep Med. 2023 May 16;4(5):101047. doi: 10.1016/j.xcrm.2023.101047.
AMPA receptors' synaptic plasticity is involved in epileptogenesis. In this issue, Eiro et al. demonstrate that Hebbian plasticity is responsible for increased AMPAR in focal seizures, while homeostatic plasticity induces the reduction of AMPAR in generalized onset seizures.
AMPA 受体的突触可塑性参与癫痫发生。在本期中，Eiro 等人证明了赫布可塑性是局灶性癫痫中 AMPAR 增加的原因，而平衡型可塑性导致全面性发作性癫痫中 AMPAR 的减少。
