Department of Biology, College of Sciences and Humanities, Prince Sattam bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Exp Parasitol. 2023 Jul;250:108548. doi: 10.1016/j.exppara.2023.108548. Epub 2023 May 15.
Annually 3.5 billion people are affected by the parasitic infections that results around 200,000 deaths per annum. Major diseases occur due to the neglected tropical parasites. Variety of methods have been used to treat the parasitic infections but now these methods have become ineffective due to the development of resistance in the parasites and some other side effects of traditional treatment methods. Previous methods include use of chemotherapeutic agents and ethnobotanicals for the treatment of parasites. Parasites have developed resistance against the chemotherapeutic agents. A major problem related to Ethnobotanicals is the unequal availability of drug at the target site which is responsible for the low efficacy of drug. Nanotechnology technology involves the manipulation of matter on a nanoscale level and has the potential to enhance the efficacy and safety of existing drugs, develop new treatments, and improve diagnostic methods for parasitic infections. Nanoparticles can be designed to selectively target parasites while minimizing toxicity to the host, and they can also be used to improve drug delivery and increase drug stability. Some important nanotechnology-based tools for parasitic control include nanoparticle-based drug delivery, nanoparticle diagnostics, nanoparticle vaccines, nanoparticle insecticides. Nanotechnology has the potential to revolutionize the field of parasitic control by providing new methods for detection, prevention and treatment of parasitic infections. This review discusses the current state of nanotechnology-based approaches for controlling parasitic infections and highlights their potential to revolutionize the field of parasitology.
每年有 35 亿人受到寄生虫感染的影响，每年因此导致约 20 万人死亡。主要疾病是由被忽视的热带寄生虫引起的。人们已经使用了多种方法来治疗寄生虫感染，但由于寄生虫产生了耐药性以及传统治疗方法的一些其他副作用，这些方法现在已经变得无效。以前的方法包括使用化学治疗药物和民族植物学来治疗寄生虫。寄生虫已经对化学治疗药物产生了耐药性。民族植物学的一个主要问题是药物在靶部位的供应不均，这导致药物的疗效降低。纳米技术涉及在纳米尺度上操纵物质，具有增强现有药物的疗效和安全性、开发新的治疗方法以及改善寄生虫感染诊断方法的潜力。纳米粒子可以被设计为选择性地针对寄生虫，同时最大限度地减少对宿主的毒性，并且还可以用于改善药物传递并增加药物稳定性。一些用于寄生虫控制的重要纳米技术工具包括基于纳米粒子的药物输送、纳米粒子诊断、纳米粒子疫苗、纳米粒子杀虫剂。纳米技术有可能通过提供寄生虫感染的检测、预防和治疗的新方法来彻底改变寄生虫控制领域。本文综述了基于纳米技术的寄生虫感染控制方法的现状，并强调了它们彻底改变寄生虫学领域的潜力。
