Research, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam 603103, Tamil Nadu, India.
Research, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam 603103, Tamil Nadu, India.
Life Sci. 2023 Aug 15;327:121785. doi: 10.1016/j.lfs.2023.121785. Epub 2023 May 15.
Each year, thousands of people suffer from traumatic peripheral nerve lesions, which impair mobility and sensibility and frequently have fatal outcomes. The recovery of peripheral nerves on its own is frequently insufficient. In this regard, cell therapy is currently one of the most cutting-edge techniques for nerve healing. The purpose of this review is to highlight the properties of various types of mesenchymal stem cells (MSCs) that are critical for peripheral nerve regeneration after nerve injury. The Preferred Reporting term used to review the available literature are "nerve regeneration," "stem cells," "peripheral nerve damage," "rat," and "human" were combined. In addition, using the phrases "stem cells" and "nerve regeneration" in PubMed, a "MeSH" search was conducted. This study describes the features of the most often utilized MSCs, as well as its paracrine potential, targeted stimulation, and propensity for differentiation into Schwann-like and neuronal-like cells. For the repair of peripheral nerve lesions, ADSCs appear to be the most relevant and promising MSCs, because of their ability to sustain and increase axonal growth, as well as their outstanding paracrine activity, putative differentiation potential, low immunogenicity, and excellent post-transplant survival rate.
每年，都有成千上万的人遭受外伤性周围神经损伤，这会损害运动和感觉功能，并且经常导致致命的后果。单纯依靠神经自身的恢复往往是不够的。在这方面，细胞疗法是目前神经修复最先进的技术之一。本文的目的是强调各种类型的间充质干细胞（MSCs）在神经损伤后周围神经再生中的关键特性。用于综述现有文献的首选报告术语是“神经再生”、“干细胞”、“周围神经损伤”、“大鼠”和“人”。此外，还在 PubMed 中使用了“干细胞”和“神经再生”这两个短语进行了“MeSH”搜索。本研究描述了最常使用的 MSCs 的特性，以及其旁分泌潜能、靶向刺激和向许旺样细胞和神经元样细胞分化的倾向。对于周围神经损伤的修复，ADSCs 似乎是最相关和最有前途的 MSCs，因为它们具有维持和增加轴突生长的能力，以及出色的旁分泌活性、潜在的分化潜能、低免疫原性和极好的移植后存活率。
