Sundström H, Ylikorkala O, Kauppila A
Carcinogenesis. 1986 Jul;7(7):1051-2. doi: 10.1093/carcin/7.7.1051.
To explore the relationships between the antioxidant selenium and pro-aggregatory thromboxane A2 in patients with gynaecological cancer, we measured the serum concentrations of selenium and the production of thromboxane B2 (TxB2, a stable metabolite of thromboxane A2) by the aggregating platelets in patients with endometrial (n = 35), ovarian (n = 30) and cervical cancer (n = 25), and in 32 control women. The selenium concentration in endometrial (1.14 +/- 0.04 mumol/l; mean +/- SE), ovarian (0.96 +/- 0.04 mumol/l) and cervical cancer (0.97 +/- 0.06 mumol/l) was significantly lower than in control subjects (1.26 +/- 0.03 mumol/l). The release of TxB2 into serum during spontaneous clotting of the blood was significantly increased in ovarian cancer (229.2 +/- 15.9 ng/ml), decreased in endometrial cancer (142.6 +/- 12.4 ng/ml) and normal in cervical cancer (185.9 +/- 14.8 ng/ml) as compared with control subjects (185.9 +/- 11.9 ng/ml). The levels of selenium and TxB2 did not correlate with each other in the whole series or in any subgroup. Thus, selenium does not seem to be an important determinant in the biosynthesis of TxB2 in patients with gynaecological malignancy.
为了探究抗氧化剂硒与妇科癌症患者体内促聚集的血栓素A2之间的关系，我们检测了子宫内膜癌患者（n = 35）、卵巢癌患者（n = 30）、宫颈癌患者（n = 25）以及32名对照女性血清中硒的浓度，以及通过聚集血小板检测血栓素B2（TxB2，血栓素A2的稳定代谢产物）的生成量。子宫内膜癌患者（1.14±0.04μmol/L；均值±标准误）、卵巢癌患者（0.96±0.04μmol/L）和宫颈癌患者（0.97±0.06μmol/L）的硒浓度显著低于对照受试者（1.26±0.03μmol/L）。与对照受试者（185.9±11.9 ng/ml）相比，血液自发凝固过程中血清中TxB2的释放量在卵巢癌患者中显著增加（229.2±15.9 ng/ml），在子宫内膜癌患者中减少（142.6±12.4 ng/ml），在宫颈癌患者中正常（185.9±14.8 ng/ml）。在整个研究组或任何亚组中，硒水平和TxB2水平均无相关性。因此，在妇科恶性肿瘤患者中，硒似乎不是TxB2生物合成的重要决定因素。
