老挝青少年对白喉和破伤风的血清保护率较低。
Low seroprotection against diphtheria and tetanus in Lao adolescents.
机构信息
Lao Tropical and Public Health Institute, Ministry of Health, Vientiane, Lao People's Democratic Republic.
Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Grand-Duchy of Luxembourg.
出版信息
Trop Med Int Health. 2023 Jun;28(6):501-506. doi: 10.1111/tmi.13882. Epub 2023 May 18.
OBJECTIVES
There is currently no booster diphtheria or tetanus vaccine for Lao children before adolescence, despite international recommendations. We investigated seroprotection against diphtheria and tetanus among Lao adolescents.
METHODS
Seven hundred seventy-nine serum samples were tested for anti-diphtheria and anti-tetanus antibodies.
RESULTS
Overall, 25.8% of the adolescents had antibody titers corresponding to protection against diphtheria and 30.9% to sufficient immunity against tetanus. Female participants >16 years were more likely to be protected against diphtheria (p < 0.001) and tetanus (p < 0.029).
CONCLUSION
Low protection against diphtheria and tetanus, possibly due to low vaccination coverage or antibody waning, suggests booster doses are warranted before adolescence.
目的
尽管有国际建议，但老挝儿童在青春期前没有加强型白喉破伤风联合疫苗。我们调查了老挝青少年对白喉和破伤风的血清保护作用。
方法
检测了 779 份血清样本的抗白喉和破伤风抗体。
结果
总体而言，25.8%的青少年对白喉具有保护作用的抗体滴度，30.9%对破伤风有足够的免疫力。16 岁以上的女性参与者更有可能对白喉（p<0.001）和破伤风（p<0.029）有保护作用。
结论
对白喉和破伤风的保护作用较低，可能是由于疫苗接种覆盖率低或抗体衰减，因此建议在青春期前进行加强剂量接种。
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