具有β细胞保护活性的茎中二萜及其糖苷。
Diterpenoids and Their Glycosides from the Stems of with Beta-Cell Protective Activity.
机构信息
School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Division of Basic Chinese Medicine, National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112, Taiwan.
出版信息
J Nat Prod. 2023 Jun 23;86(6):1437-1448. doi: 10.1021/acs.jnatprod.3c00114. Epub 2023 May 18.
Seven previously undescribed diterpenoids, tinocrisposides A-D (-) and borapetic acids A (), B (), and C (), together with 16 known compounds, were isolated from the stem of (Menispermaceae). The structures of the new isolates were elucidated by spectroscopic and chemical methods. The β-cell protective effect of the tested compounds was examined on insulin-secreting BRIN-BD11 cells under dexamethasone treatment. Diterpene glycosides , -, and presented a substantial protective effect on BRIN-BD11 cells treated with dexamethasone in a dose-dependent manner. Compounds and with two sugar moieties exhibited clear protective effects on β-cells.
从 （防己科）的茎中分离得到了七个以前未描述的二萜类化合物，锡诺克里斯波甙 A-D（-）和硼替酸 A（）、B（）和 C（），以及 16 个已知化合物。通过光谱和化学方法阐明了新分离物的结构。在 dexamethasone 处理下，测试化合物对胰岛素分泌 BRIN-BD11 细胞的β细胞保护作用进行了研究。二萜糖苷 、 、 和 以剂量依赖的方式对 BRIN-BD11 细胞具有显著的保护作用。具有两个糖基的化合物 和 对β细胞具有明显的保护作用。
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