Department of Internal Medicine, School of Medicine, Pusan National University, Busan, Korea.
Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
PLoS One. 2023 May 18;18(5):e0286004. doi: 10.1371/journal.pone.0286004. eCollection 2023.
The prevalence of multiple chronic conditions (MCC), defined as several coexisting chronic conditions, has increased with the aging of society. MCC is associated with poor outcomes, but most comorbid diseases in asthma patients have been evaluated as asthma-associated diseases. We investigated the morbidity of coexisting chronic diseases in asthma patients and their medical burdens.
We analyzed data from the National Health Insurance Service-National Sample Cohort for 2002-2013. We defined MCC with asthma as a group of one or more chronic diseases in addition to asthma. We analyzed 20 chronic conditions, including asthma. Age was categorized into groups 1-5 (< 10, 10-29, 30-44, 45-64, and ≥ 65 years, respectively). The frequency of medical system use and associated costs were analyzed to determine the asthma-related medical burden in patients with MCC.
The prevalence of asthma was 13.01%, and the prevalence of MCC in asthmatic patients was 36.55%. The prevalence of MCC with asthma was higher in females than males and increased with age. The significant comorbidities were hypertension, dyslipidemia, arthritis, and diabetes. Dyslipidemia, arthritis, depression, and osteoporosis were more common in females than males. Hypertension, diabetes, COPD, coronary artery disease, cancer, and hepatitis were more prevalent in males than females. According to age, the most prevalent chronic condition in groups 1 and 2 was depression, dyslipidemia in group 3, and hypertension in groups 4 and 5. Older age, low income, and severe disability were independent risk factors for MCC in patients with asthma. The frequency of asthma-related medical system use and asthma-associated costs increased with increasing numbers of coexisting chronic diseases.
Comorbid chronic diseases in asthma patients differed according to age and sex. The asthma-related-medical burdens were highest in patients with five or more chronic conditions and groups 1 and 5.
随着社会老龄化，多种慢性疾病（MCC）的患病率增加，定义为几种共存的慢性疾病。MCC 与不良结局相关，但哮喘患者的大多数合并疾病都被评估为哮喘相关疾病。我们调查了哮喘患者共存慢性疾病的发病率及其医疗负担。
我们分析了 2002-2013 年国家健康保险服务-国家样本队列的数据。我们将哮喘合并 MCC 定义为除哮喘以外还患有一种或多种慢性疾病的一组疾病。我们分析了 20 种慢性疾病，包括哮喘。年龄分为 1-5 组（分别为<10、10-29、30-44、45-64 和≥65 岁）。分析了医疗系统使用的频率和相关费用，以确定 MCC 患者的哮喘相关医疗负担。
哮喘的患病率为 13.01%，哮喘患者 MCC 的患病率为 36.55%。女性哮喘合并 MCC 的患病率高于男性，且随年龄增长而增加。主要合并症为高血压、血脂异常、关节炎和糖尿病。女性中血脂异常、关节炎、抑郁和骨质疏松症比男性更常见。男性中高血压、糖尿病、COPD、冠心病、癌症和肝炎比女性更常见。按年龄分组，1 组和 2 组最常见的慢性疾病是抑郁，3 组是血脂异常，4 组和 5 组是高血压。年龄较大、收入较低和严重残疾是哮喘患者 MCC 的独立危险因素。哮喘相关医疗系统使用频率和哮喘相关费用随共存慢性疾病数量的增加而增加。
哮喘患者的合并慢性疾病因年龄和性别而异。有五种或更多慢性疾病以及年龄在 1 组和 5 组的患者哮喘相关医疗负担最高。
