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儿童炎症性肠病性葡萄膜炎。

Uveitis in pediatric inflammatory bowel disease.

机构信息

University of Southern California Roski Eye Institute, Los Angeles, California.

Department of Ophthalmology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

出版信息

J AAPOS. 2023 Jun;27(3):153-155. doi: 10.1016/j.jaapos.2023.02.013. Epub 2023 May 17.

Abstract

There are currently no official uveitis screening guidelines for children with inflammatory bowel disease (IBD). In this retrospective cohort study of children with IBD with at least 1 ophthalmologist examination over 12 years, we investigated the prevalence and characteristics of uveitis in pediatric IBD. Outcomes included prevalence of uveitis, age at onset, and clinical characteristics of uveitis. A total of 315 children with IBD (mean age, 11.7 ± 4.3) had 974 eye examinations. Five children (1.6%; 95% CI, 0.7%-3.7%) had uveitis, with mean age at onset of 14.3 ± 5.6 years. Three of 209 children with Crohn's disease (1.4%; 95% CI, 0.5%-4.1%), 2 of 55 with IBD-unclassified (3.6%; 95% CI, 1.0%-12.3%) and 0 of 51 with ulcerative colitis (95% CI, 0.0%-7.0%) had uveitis. All uveitis was symptomatic. In our study cohort, uveitis was rare and symptomatic in pediatric IBD.

摘要

目前,针对炎症性肠病(IBD)患儿,尚无官方的葡萄膜炎筛查指南。在这项回顾性队列研究中,我们对至少接受过 12 年 1 次眼科检查的 IBD 患儿进行了研究,旨在调查小儿 IBD 患者中葡萄膜炎的患病率和特征。研究结局包括葡萄膜炎的患病率、发病年龄和葡萄膜炎的临床特征。共有 315 名 IBD 患儿(平均年龄 11.7 ± 4.3 岁)接受了 974 次眼部检查。5 名患儿(1.6%;95%CI,0.7%-3.7%)患有葡萄膜炎,发病年龄平均为 14.3 ± 5.6 岁。209 名克罗恩病患儿中有 3 名(1.4%;95%CI,0.5%-4.1%)、55 名未分类 IBD 患儿中有 2 名(3.6%;95%CI,1.0%-12.3%)和 51 名溃疡性结肠炎患儿中均未发生葡萄膜炎(95%CI,0.0%-7.0%)。所有葡萄膜炎均为症状性。在本研究队列中,小儿 IBD 患者中葡萄膜炎的发病率较低且为症状性。

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