Rheumatology Unit, ERN-ReCONNET Center, Meyer Children Hospital IRCCS, Florence, Italy.
Gastroenterology and Nutrition Unit, Meyer Children Hospital IRCCS, Florence, Italy.
J Pediatr Gastroenterol Nutr. 2024 Jun;78(6):1305-1309. doi: 10.1002/jpn3.12216. Epub 2024 Apr 9.
Inflammatory bowel diseases (IBD) encompass a group of chronic inflammatory disorders primarily affecting the gastrointestinal tract but capable of impacting various organs, including the eye, with uveitis being the most common ocular condition. We assessed uveitis prevalence and clinical features in a nationwide cohort of pediatric IBD. Among 4229 cases, six patients (four Crohn's disease, one ulcerative colitis, and one unclassified IBD) were identified, resulting in an overall prevalence rate of 141.8 per 100,000 patients. Uveitis onset varied: two before IBD, two after, and two concomitantly. Symptomatic uveitis occurred in 2/6 patients, with anterior involvement in all cases. Median follow-up was 3 years (interquartile range 2-4.75 years). At the last follow-up, 5/6 patients exhibited quiescent IBD, while 4/6 had inactive uveitis. One patient had ocular complications. Uveitis is a rare but potentially complicating manifestation of pediatric IBD.
炎症性肠病(IBD)包括一组主要影响胃肠道的慢性炎症性疾病,但也能够影响包括眼睛在内的各种器官,其中葡萄膜炎是最常见的眼部疾病。我们评估了全国性儿科 IBD 队列中葡萄膜炎的患病率和临床特征。在 4229 例病例中,发现了 6 例患者(4 例克罗恩病、1 例溃疡性结肠炎和 1 例未分类的 IBD),总患病率为每 10 万人中有 141.8 例。葡萄膜炎的发病时间不同:2 例在 IBD 之前,2 例在 IBD 之后,2 例同时发生。2/6 例患者出现症状性葡萄膜炎,所有病例均为前葡萄膜炎。中位随访时间为 3 年(四分位间距 2-4.75 年)。在最后一次随访时,5/6 例患者的 IBD 处于静止状态,4/6 例患者的葡萄膜炎处于非活动状态。1 例患者出现眼部并发症。葡萄膜炎是儿科 IBD 的一种罕见但潜在的并发症。