Zhong Junpei, Zong Siwen, Wang Jiayang, Feng Mingrui, Wang Jie, Zhang Hongyan, Xiong Lixia
Department of Pathophysiology, Medical College, Nanchang University, Nanchang 330006, China.
Second Clinical Medical College, Nanchang University, Nanchang 330006, China.
Biochim Biophys Acta Mol Cell Res. 2023 Oct;1870(7):119493. doi: 10.1016/j.bbamcr.2023.119493. Epub 2023 May 17.
The notion that neutrophils only perform a specific set of single functions in the body has changed with the advancement of research methods. As the most abundant myeloid cells in human blood, neutrophils are currently emerging as important regulators of cancer. Given the duality of neutrophils, neutrophil-based tumor therapy has been clinically carried out in recent years and has made some progress. But due to the complexity of the tumor microenvironment, the therapeutic effect is still not satisfactory. Therefore, in this review, we discuss the direct interaction of neutrophils with the five most common cancer cells and other immune cells in the tumor microenvironment. Also, this review covered current limitations, potential future possibilities, and therapeutic approaches targeting neutrophil function in cancer therapy.
随着研究方法的进步，认为中性粒细胞仅在体内执行特定一组单一功能的观念已经发生了改变。作为人类血液中最丰富的髓样细胞，中性粒细胞目前正成为癌症的重要调节因子。鉴于中性粒细胞的双重性，基于中性粒细胞的肿瘤治疗近年来已在临床上开展并取得了一些进展。但由于肿瘤微环境的复杂性，治疗效果仍不尽人意。因此，在本综述中，我们讨论了中性粒细胞与肿瘤微环境中五种最常见癌细胞及其他免疫细胞的直接相互作用。此外，本综述还涵盖了当前的局限性、未来潜在的可能性以及癌症治疗中针对中性粒细胞功能的治疗方法。
