Hou Xiaoyu, Jie Chuanhong, Liu Ziqiang, Bi Xuqi, Deng Yu, Li Yuanyuan, Wang Jingying, Zhang Weiqiong
Eye Hospital China Academy of Chinese Medical Sciences, Beijing, China.
Front Neurosci. 2024 Apr 15;18:1368957. doi: 10.3389/fnins.2024.1368957. eCollection 2024.
Internal carotid artery stenosis (ICAS) is a prevalent vascular condition associated with ischemic cerebrovascular disease. The ophthalmic artery is the first branch of the internal carotid artery stenosis (ICA). Given the crucial role of the ICA in ocular perfusion, we aimed to assess the thickness and vessel density of the retina and choroid in individuals with ICAS.
The PubMed and Embase databases were searched from inception to 10 January 2023 for studies evaluating retinal and choroidal changes between ICAS patients and healthy controls using optical coherence tomography (OCT) or optical coherence tomography angiography (OCTA). Data of interest were extracted and analyzed using Stata software version 16.
Thirteen studies involving 419 ICAS eyes and 398 healthy eyes were included. The pooled results demonstrated that the average thickness of peripapillary retinal nerve fiber layer (pRNFL) (WMD = -0.26, 95% CI: -0.45 to -0.08, = 0.005), ganglion cell complex (GCC) (WMD = -0.36, 95% CI: -0.65 to -0.06, = 0.017), and choroid (WMD = -1.06, 95% CI: -1.59 to -0.52, = 0.000), were significantly thinner in patients with ICAS than in healthy controls. The overall vessel density of the radial peripapillary capillaries (RPC) in whole-image scans was lower in ICAS patients than in healthy control subjects (WMD = -0.94, 95% CI: -1.49 to -0.39, = 0.001). No differences were detected in the vessel density of the superficial capillary plexus (SCP) (WMD = -0.84, 95% CI: -1.15 to -0.53, = 0.092), the deep capillary plexus (DCP) (WMD = -0.27, 95% CI: -0.56 to 0.03, = 0.074), or the choriocapillaris (CC) (WMD = -0.39, 95% CI: -1.12 to 0.35, = 0.300).
This systematic review and meta-analysis demonstrated that ICAS can reduce the vessel density of the RPC and the thickness of the retina and choroid. The retinal and choroidal microvasculature is a potential biomarker of the initial signal of ICAS.
https://inplasy.com/, identifier NPLASY202410038.
颈内动脉狭窄（ICAS）是一种与缺血性脑血管疾病相关的常见血管疾病。眼动脉是颈内动脉（ICA）的第一分支。鉴于ICA在眼部灌注中的关键作用，我们旨在评估ICAS患者视网膜和脉络膜的厚度及血管密度。
检索PubMed和Embase数据库自建库至2023年1月10日的研究，这些研究使用光学相干断层扫描（OCT）或光学相干断层扫描血管造影（OCTA）评估ICAS患者与健康对照之间的视网膜和脉络膜变化。使用Stata软件16版提取并分析感兴趣的数据。
纳入13项研究，涉及419只ICAS眼和398只健康眼。汇总结果表明，ICAS患者视乳头周围视网膜神经纤维层（pRNFL）（加权均数差[WMD]=-0.26，95%置信区间[CI]：-0.45至-0.08，P=0.005）、神经节细胞复合体（GCC）（WMD=-0.36，95%CI：-0.65至-0.06，P=0.017）和脉络膜（WMD=-1.06，95%CI：-1.59至-0.52，P=0.000）的厚度显著低于健康对照。全图像扫描中，ICAS患者视乳头周围放射状毛细血管（RPC）的总体血管密度低于健康对照（WMD=-0.94，95%CI：-1.49至-0.39，P=0.001）。在浅表毛细血管丛（SCP）（WMD=-0.84，95%CI：-1.15至-0.53，P=0.092）、深部毛细血管丛（DCP）（WMD=-0.27，95%CI：-0.56至0.03，P=0.074）或脉络膜毛细血管（CC）（WMD=-0.39，95%CI：-1.12至0.35，P=0.300）的血管密度方面未检测到差异。
本系统评价和荟萃分析表明，ICAS可降低RPC的血管密度以及视网膜和脉络膜的厚度。视网膜和脉络膜微血管是ICAS初始信号的潜在生物标志物。
