扫频源光学相干断层扫描血管造影（SS-OCTA）评估非动脉炎性前部缺血性视神经病变（NAION）的视盘特征：一项横断面研究。

Optic disc characteristics evaluated with swept source optical coherence tomography angiography (SS-OCTA) in nonarteritic anterior ischemic optic neuropathy (NAION): a cross-sectional study.

作者信息

Ren Dazhuang, Li Wenjing, Li Chang, Yang Shu, Zhao Cece, Hou Xiaoyun, Xing Dongjun, Yu Rongguo, Li Zhiqing

机构信息

Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute, School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, China.

The First Hospital of Kunming, Kunming, Yunnan, China.

出版信息

BMC Ophthalmol. 2025 Apr 2;25(1):166. doi: 10.1186/s12886-025-04002-1.

DOI:10.1186/s12886-025-04002-1

PMID:40175979

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11963473/

Abstract

BACKGROUND

Nonarteritic anterior ischemic optic neuropathy (NAION) is one of common optic neuropathies affect optic disc. But the structure of optic disc in NAION remains poorly understood. Our aim was to identify optic disc characteristics of NAION.

METHODS

This cross-sectional study included chronic-stage affected eyes and unaffected eyes from NAION patients and normal eyes from age-matched individuals. Measurements of optic disc and macula from swept source optical coherence tomography angiography (SS-OCTA) were recorded. Besides conventional OCTA parameters, we also manually measured circumpapillary retinal nerve fiber layer (cRNFL) thickness, lamina cribrosa depth (LCD) and prelaminar tissue thickness (PLTT). Additionally, we introduced a new parameter, retinal nerve fiber layer density (RNFLD).

RESULTS

This study finally included 53 NAION-fellow eyes, 26 chronic-stage NAION eyes and 50 normal eyes. NAION-fellow eyes and NAION eyes showed significantly thicker PLTT compared to normal eyes (p < 0.001). NAION fellow eyes showed similar peripapillary retinal nerve fiber layer (pRNFL) thickness but significantly thicker cRNFL (p < 0.001) compared to normal eyes. And NAION eyes showed significantly thinner pRNFL (p < 0.001) but similar cRNFL compared to normal eyes. RNFLD was higher in NAION-fellow eyes compared to the other two groups (p < 0.01). Logistic analyses showed PLTT was independently associated with NAION susceptibility (OR = 1.017, 95% CI: 1.009-1.025, p < 0.001). ROC curve of PLTT showed that the area under the curve (AUC) was 0.905 (95% CI: 0.846-0.964, p < 0.001).

CONCLUSIONS

Both affected and unaffected eyes of NAION patients exhibited an increase in non-nerve fiber components within the retinal nerve fiber layer at optic disc. These increased components might be glial tissue or the remnants of the primitive vitreous. Additionally, PLTT was an independent susceptibility factor for NAION.

摘要

背景

非动脉炎性前部缺血性视神经病变（NAION）是常见的影响视盘的视神经病变之一。但NAION中视盘的结构仍了解甚少。我们的目的是确定NAION的视盘特征。

方法

这项横断面研究纳入了NAION患者的慢性期患眼和未患眼以及年龄匹配个体的正常眼。记录了扫频源光学相干断层扫描血管造影（SS-OCTA）对视盘和黄斑的测量结果。除了传统的OCTA参数外，我们还手动测量了视乳头周围视网膜神经纤维层（cRNFL）厚度、筛板深度（LCD）和板前组织厚度（PLTT）。此外，我们引入了一个新参数，即视网膜神经纤维层密度（RNFLD）。

结果

本研究最终纳入了53只NAION对侧眼、26只慢性期NAION患眼和50只正常眼。与正常眼相比，NAION对侧眼和NAION患眼的PLTT明显更厚（p<0.001）。与正常眼相比，NAION对侧眼的视乳头周围视网膜神经纤维层（pRNFL）厚度相似，但cRNFL明显更厚（p<0.001）。与正常眼相比，NAION患眼的pRNFL明显更薄（p<0.001），但cRNFL相似。与其他两组相比，NAION对侧眼的RNFLD更高（p<0.01）。逻辑分析显示PLTT与NAION易感性独立相关（OR=1.017，95%CI：1.009-1.025，p<0.001）。PLTT的ROC曲线显示曲线下面积（AUC）为0.905（95%CI：0.846-0.964，p<0.001）。