Key Laboratory of Marine Eco-Environmental Science and Technology, First Institute of Oceanography, Ministry of Natural Resources, Qingdao, China.
Laboratory of Marine Ecology and Environmental Science, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao, China.
J Anim Physiol Anim Nutr (Berl). 2023 Sep;107(5):1198-1205. doi: 10.1111/jpn.13832. Epub 2023 May 18.
Blidingia sp. is a prominent fouling green macroalga and we previously found that extracts from Blidingia sp. alleviated intestinal inflammation in mice challenged with lipopolysaccharides. However, whether these extracts are effective in weanling piglets remains unknown. In the present study, Blidingia sp. extracts were supplemented in the diet and their effects on growth performance, incidence of diarrhoea and intestinal function in weanling piglets were explored. The results showed that diets supplemented with 0.1% or 0.5% Blidingia sp. extract significantly increased average daily body weight gain and feed intake in weanling piglets. Meanwhile, piglets supplemented with 0.5% Blidingia sp. extract showed decreased incidence of diarrhoea as well as reduced fecal water and Na content. Furthermore, the diet supplemented with 0.5% Blidingia sp. extracts improved intestinal morphology, as indicated by the results of hematoxylin and eosin staining. Diet supplemented with 0.5% Blidingia sp. extracts also improved tight junction function, as indicated by increased expression of Occludin, Claudin-1 and Zonula occludens-1, and alleviated the inflammatory response, as indicated by decreased tumor necrosis factor-α and interleukin-6 (IL6) contents and increased IL10 levels. Taken together, our results showed that Blidingia sp. extracts had beneficial effects in weanling piglets and we suggest that Blidingia sp. extracts could be potentially used as an additive for piglets.
螺旋藻是一种常见的污损绿藻，我们之前发现螺旋藻提取物可缓解脂多糖刺激的小鼠肠道炎症。然而，这些提取物在断奶仔猪中的有效性尚不清楚。本研究在日粮中添加螺旋藻提取物，探讨其对断奶仔猪生长性能、腹泻发生率和肠道功能的影响。结果表明，日粮中添加 0.1%或 0.5%螺旋藻提取物可显著提高断奶仔猪的平均日增重和采食量。同时，添加 0.5%螺旋藻提取物可降低仔猪腹泻发生率，降低粪便含水量和 Na 含量。此外，日粮中添加 0.5%螺旋藻提取物可改善肠道形态，这可通过苏木精-伊红染色结果得到证实。添加 0.5%螺旋藻提取物还可改善紧密连接功能，上调 Occludin、Claudin-1 和 Zonula occludens-1 的表达，并缓解炎症反应，降低肿瘤坏死因子-α和白细胞介素-6（IL6）含量，增加白细胞介素-10（IL10）水平。综上所述，本研究结果表明螺旋藻提取物对断奶仔猪具有有益作用，提示螺旋藻提取物可作为仔猪的潜在添加剂。
