Song Wei, Li Yan, Zhang Xuelei, Wang Zongling
Key Laboratory of Science and Engineering for Marine Ecology and Environment, The First Institute of Oceanography, Ministry of Natural Resources of the People's Republic of China, Qingdao, China.
Laboratory of Marine Ecology and Environmental Science, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China.
Front Physiol. 2019 Jun 25;10:763. doi: 10.3389/fphys.2019.00763. eCollection 2019.
sp. is a green alga that has spread rapidly in Subei Shoal, China. To explore the potential beneficial effects of sp., we investigated the anti-inflammatory activity of its water-methanol extract of sp. in a mouse model of lipopolysaccharide (LPS)-induced intestinal inflammation. The results revealed that the administration of extract significantly alleviated the LPS-induced increase of the inflammatory cytokine content in the serum, as well as latter's gene expression in the ileum. Moreover, the extract inhibited the phosphorylation of NF-κB and IκBα in LPS-challenged mice. Apart from these changes, the extract also averted intestinal morphology damage(s) and cell apoptosis in mice. Interestingly, the extract also had beneficial effects on the diversity and composition of caecal microbiota in LPS-challenged mice. In conclusion, the results suggested that extract had beneficial effects on the recovery of intestinal function by reducing the inflammatory response, improving the maintenance of intestinal morphology, and decreasing cell apoptosis in LPS-induced intestinal inflammation. In addition, the beneficial effects of the extract on caecal microbiota composition may play a role in its anti-inflammatory activity. These results suggested that extract could be potentially used in preventing intestinal inflammation.
[藻种名称]是一种绿藻，在中国苏北浅滩迅速蔓延。为了探索[藻种名称]的潜在有益作用，我们在脂多糖（LPS）诱导的肠道炎症小鼠模型中研究了其水-甲醇提取物的抗炎活性。结果显示，给予[提取物名称]提取物可显著减轻LPS诱导的血清中炎症细胞因子含量的增加以及回肠中后者基因的表达。此外，该提取物抑制了LPS攻击小鼠中NF-κB和IκBα的磷酸化。除了这些变化外，该提取物还避免了小鼠肠道形态损伤和细胞凋亡。有趣的是，该提取物对LPS攻击小鼠的盲肠微生物群的多样性和组成也有有益影响。总之，结果表明[提取物名称]提取物通过减轻炎症反应、改善肠道形态维持和减少LPS诱导的肠道炎症中的细胞凋亡，对肠道功能的恢复具有有益作用。此外，该提取物对盲肠微生物群组成的有益作用可能在其抗炎活性中发挥作用。这些结果表明[提取物名称]提取物可能潜在地用于预防肠道炎症。
