Takeda K, Shimada Y, Okada T, Amano M, Sakai T, Yoshiya I
Crit Care Med. 1986 Aug;14(8):719-23. doi: 10.1097/00003246-198608000-00010.
We previously reported increased lipid peroxide and decreased alpha-tocopherol levels in the blood of critically ill septic patients. To clarify these results, we investigated lipid peroxidation in experimental septic rats and severely traumatized rats. In septic rats, both platelet count and plasma alpha-tocopherol decreased significantly, while lipid peroxide in plasma and major organs significantly increased. Serum transaminases also increased significantly. Traumatized rats had a significant but transient decrease in platelet count and a continuous decrease in plasma alpha-tocopherol; lipid peroxide did not change significantly in the plasma but increased significantly in the lung and kidney. Serum transaminases of traumatized rats showed transient increases. Thus, although traumatic stress caused lipid peroxidation similar to sepsis in the major organs, plasma lipid peroxide did not change.
我们之前报道过，危重症脓毒症患者血液中的脂质过氧化物增加，α-生育酚水平降低。为了阐明这些结果，我们研究了实验性脓毒症大鼠和严重创伤大鼠的脂质过氧化情况。在脓毒症大鼠中，血小板计数和血浆α-生育酚均显著降低，而血浆和主要器官中的脂质过氧化物显著增加。血清转氨酶也显著升高。创伤大鼠的血小板计数显著但短暂下降，血浆α-生育酚持续下降；血浆中的脂质过氧化物无显著变化，但肺和肾中的脂质过氧化物显著增加。创伤大鼠的血清转氨酶呈短暂升高。因此，尽管创伤应激在主要器官中引起了与脓毒症类似的脂质过氧化，但血浆脂质过氧化物并未改变。
