Takeda K, Shimada Y, Amano M, Sakai T, Okada T, Yoshiya I
Crit Care Med. 1984 Nov;12(11):957-9. doi: 10.1097/00003246-198411000-00007.
Plasma lipid peroxide measured as thiobarbituric acid reactive substances (TBARS) and alpha-tocopherol levels in 24 critically ill patients were compared with those of control subjects. The mean plasma alpha-tocopherol level was significantly lower and the mean TBARS level was significantly higher in critically ill patients. Eight ICU patients developed disseminated intravascular coagulation (DIC); the mean TBARS level during DIC was significantly above the mean pre-DIC level. These results indicate that lipid peroxidation may contribute to the development of DIC in critically ill patients.
对24例危重症患者的血浆脂质过氧化物（以硫代巴比妥酸反应性物质（TBARS）衡量）水平和α-生育酚水平与对照组进行了比较。危重症患者的血浆α-生育酚平均水平显著降低，TBARS平均水平显著升高。8例ICU患者发生了弥散性血管内凝血（DIC）；DIC期间的TBARS平均水平显著高于DIC前的平均水平。这些结果表明，脂质过氧化可能在危重症患者DIC的发生中起作用。
