Bootstrapping and added data discriminate, at low blood pressures, neuroendocrine risk of developing mesor-hypertension.

Under room-restricted conditions in a clinical research center, blood pressure and circulating aldosterone and TSH, sampled along 24-h and seasonal scales, reveal differences between small groups of young adult clinically healthy women at high or low risk of developing a high blood pressure. In view of the small sample sizes, data on additional age groups were added and both the original and the extended samples were further analyzed by bootstrapping. Monte Carlo procedures thus applied support the validity of the rhythm-stage-dependent endocrine and blood pressure differences as a function of the risk of developing a high blood pressure.