School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou 510275, China.
Int J Mol Sci. 2022 Feb 21;23(4):2370. doi: 10.3390/ijms23042370.
Local drug delivery is an effective strategy for achieving direct and instant therapeutic effects. Current clinical treatments have fallen short and are limited by traditional technologies. Bioadhesive nanoparticles (NPs), however, may be a promising carrier for optimized local drug delivery, offering prolonged drug retention time and steadily maintained therapeutic concentrations. In addition, the possibility of clinical applications of this platform are abundant, as most polymers used for bioadhesion are both biodegradable and biocompatible. This review highlights the major advances in the investigations of polymer-based bioadhesive nanoparticles and their innumerable applications in local drug delivery.
局部给药是实现直接和即时治疗效果的有效策略。当前的临床治疗方法受到传统技术的限制，效果有限。然而，生物黏附纳米粒子（NPs）可能是优化局部药物输送的有前途的载体，提供延长的药物滞留时间和稳定维持的治疗浓度。此外，该平台的临床应用可能性丰富，因为大多数用于生物黏附的聚合物既具有生物降解性又具有生物相容性。本文综述了基于聚合物的生物黏附纳米粒子的研究进展及其在局部药物输送中的广泛应用。
