Makwe Christian C, Soibi-Harry Adaiah P, Rimi Garba S, Ugwu Okechukwu A, Ajayi Abisoye T, Adesina Taiwo A, Okunade Kehinde S, Oluwole Ayodeji A, Anorlu Rose I
Obstetrics and Gynaecology, Lagos University Teaching Hospital/College of Medicine, University of Lagos, Lagos, NGA.
Obstetrics and Gynaecology, Lagos University Teaching Hospital, Lagos, NGA.
Cureus. 2021 Oct 10;13(10):e18638. doi: 10.7759/cureus.18638. eCollection 2021 Oct.
Uterine fibroids significantly affect the quality of life of reproductive-age women. The socioeconomic cost and psychological strain on patients cannot be overemphasized. The role of diet and micronutrients on the onset and development of uterine fibroids has come under review in recent times. This study assessed the levels of some micronutrients and trace elements in the serum of women with uterine fibroids.
Eighty-eight women were recruited from the Gynecology Outpatient Clinic of Lagos University Teaching Hospital, 44 with uterine fibroids and 44 women without uterine fibroids. Blood samples were obtained and analyzed for serum levels of selected micronutrients (vitamins A, C, D, and E) and trace elements (calcium, magnesium, and phosphorus). Pelvic ultrasonography was performed on all study participants.
Women with uterine fibroids had statistically significant lower serum levels of vitamin C (1.20 ± 0.59 vs 1.62 ± 1.75 mg/dl; p = 0.01), vitamin D (34.23 ±10.67 vs 37.06 ±11.46 ng/ml; p = 0.04), and calcium (2.27 ± 0.19 vs 2.32 ± 0.09 mmol/L; p = 0.02) compared with women without uterine fibroids. There was no significant difference in the serum levels of vitamins A (39.63 ± 15.71 vs 40.09 ±15.26 μ/dl; p = 0.91), vitamin E (5.44 ± 4.65 vs 5.26 ± 4.62 µg/mL; p = 0.87), magnesium (0.89 ± 0.09 vs 0.89 ± 0.08 mmol/L; p = 0.78), and phosphorus (1.29 ± 0.38 vs 1.19 ± 0.17 mmol/L; p = 0.14) in women with uterine fibroids compared to those without uterine fibroids.
This study showed lower serum levels of vitamin C, vitamin D, and calcium in women with uterine fibroids when compared to women without uterine fibroids. It is possible that these micronutrients and trace elements may play a role in the etiopathogenesis, progression, and/or proliferation of uterine fibroids. However, whether the findings of low serum levels of these elements are a cause or an effect of uterine fibroid, is yet to be determined.
子宫肌瘤严重影响育龄妇女的生活质量。患者所承受的社会经济成本和心理压力再怎么强调都不为过。近年来，饮食和微量营养素对子宫肌瘤发病及发展的作用受到了审视。本研究评估了子宫肌瘤患者血清中某些微量营养素和微量元素的水平。
从拉各斯大学教学医院妇科门诊招募了88名女性，其中44名患有子宫肌瘤，44名未患子宫肌瘤。采集血样并分析所选微量营养素（维生素A、C、D和E）和微量元素（钙、镁和磷）的血清水平。对所有研究参与者进行盆腔超声检查。
与未患子宫肌瘤的女性相比，患子宫肌瘤的女性血清维生素C水平（1.20±0.59 vs 1.62±1.75mg/dl；p = 0.01）、维生素D水平（34.23±10.67 vs 37.06±11.46ng/ml；p = 0.04）和钙水平（2.27±0.19 vs 2.32±0.09mmol/L；p = 0.02）在统计学上显著较低。患子宫肌瘤的女性与未患子宫肌瘤的女性相比，血清维生素A水平（39.63±15.71 vs 40.09±15.26μ/dl；p = 0.91）、维生素E水平（5.44±4.65 vs 5.26±4.62μg/mL；p = 0.87）、镁水平（0.89±0.09 vs 0.89±0.08mmol/L；p = 0.78）和磷水平（1.29±0.38 vs 1.19±0.17mmol/L；p = 0.14）无显著差异。
本研究表明，与未患子宫肌瘤的女性相比，患子宫肌瘤的女性血清维生素C、维生素D和钙水平较低。这些微量营养素和微量元素可能在子宫肌瘤的发病机制、进展和/或增殖中起作用。然而，这些元素血清水平低的发现是子宫肌瘤的原因还是结果，尚待确定。
