沙特阿拉伯特应性皮炎患儿的眼部表现
Ocular manifestations of children with atopic dermatitis in Saudi Arabia.
作者信息
Raffa Lina Hassan, Roblah Tala Musa, Balbaid Nasser Talal, Zimmo Bader Sameer, Showail Mahmood Jameel
机构信息
Department of Ophthalmology, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.
Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
出版信息
Int J Ophthalmol. 2023 May 18;16(5):787-793. doi: 10.18240/ijo.2023.05.17. eCollection 2023.
AIM
To examine the incidence of ocular abnormalities in children with atopic dermatitis (AD) in Saudi Arabia and its association with the severity of AD.
METHODS
This is a cross-sectional study on 50 children with AD who were between 5 and 16 years of age. The severity of AD was evaluated using the SCORing Atopic Dermatitis (SCORAD) index. All the children underwent slit lamp exams, visual acuity assessment, intraocular pressure measurement, and corneal topography. The children were considered to have an ophthalmic abnormality if one or more of the following signs were present: glaucoma, keratoconus suspicion, in addition to lid, conjunctival, corneal, lenticular, or retinal abnormalities.
RESULTS
Based on the SCORAD severity index, 14% of children had mild AD (7/50), 38% had moderate AD (19/50), and nearly half had severe AD. More than half the children exhibited facial involvement, and half had peri-orbital signs. The mean SCORAD index was 35.75. The mean age was 10.48±3.6y, and the cohort showed a slight male predominance (54% males). Both eyes of the 50 children in the cohort were studied. Based on the ocular examinations, 92% of the patients showed ocular abnormalities: lid abnormalities (27/50) followed by keratitis (22/50). Four patients had moderate risk for keratoconus in one eye and eight patients were suspected to have keratoconus. However, SCORAD severity index was not associated with age, sex, or the number or presence of ophthalmic abnormalities.
CONCLUSION
This is the first study in Saudi Arabia to evaluate the prevalence of ocular manifestations in children with AD. The results indicate that the majority of children with AD have ocular abnormalities that mainly include lid abnormalities. Based on these findings, larger scale studies are needed to affirm whether regular screening for ophthalmic abnormalities would be beneficial for children with AD in terms of early intervention and prevention of sight-threatening complications.
目的
研究沙特阿拉伯特应性皮炎（AD）患儿眼部异常的发生率及其与AD严重程度的关系。
方法
这是一项针对50名年龄在5至16岁之间的AD患儿的横断面研究。采用特应性皮炎评分（SCORAD）指数评估AD的严重程度。所有患儿均接受裂隙灯检查、视力评估、眼压测量和角膜地形图检查。如果出现以下一种或多种体征，则认为患儿存在眼部异常：青光眼、圆锥角膜可疑，以及眼睑、结膜、角膜、晶状体或视网膜异常。
结果
根据SCORAD严重程度指数，14%的患儿患有轻度AD（7/50），38%患有中度AD（19/50），近一半患有重度AD。超过一半的患儿有面部受累，一半有眶周体征。SCORAD指数的平均值为35.75。平均年龄为10.48±3.6岁，该队列中男性略占优势（54%为男性）。对队列中的50名患儿的双眼进行了研究。根据眼部检查，92%的患者存在眼部异常：眼睑异常（27/50），其次是角膜炎（22/50）。4名患者一只眼中度圆锥角膜风险，8名患者疑似圆锥角膜。然而，SCORAD严重程度指数与年龄、性别或眼部异常的数量或存在情况无关。
结论
这是沙特阿拉伯首次评估AD患儿眼部表现患病率的研究。结果表明，大多数AD患儿存在眼部异常，主要包括眼睑异常。基于这些发现，需要进行更大规模的研究，以确定定期筛查眼部异常对AD患儿在早期干预和预防视力威胁性并发症方面是否有益。
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