Towell Vincent, Gysen Kirsten Van, Cross Shamira, Kk Low Gary
Department of Radiation Oncology, Nepean Hospital Cancer Care Centre, Sydney, Australia.
Nepean Clinical School, University of Sydney, Sydney, Australia.
Tech Innov Patient Support Radiat Oncol. 2023 May 4;26:100208. doi: 10.1016/j.tipsro.2023.100208. eCollection 2023 Jun.
End expiration breath hold (EEBH) is the preferred motion management method for abdominal Stereotactic Ablative Body Radiotherapy (SABR) treatments. However, multiple short EEBHs are required to complete a single treatment session. The study aimed to determine the efficacy of preoxygenation with hyperventilation in extending an EEBH duration.
We randomised 10 healthy participants into two arms, each included breathing room air and oxygen at a rate of 10 L per minute (l/min) without hyperventilation for four minutes, and normally for four minutes and with hyperventilation for one minute at a rate of 20 breaths/minute for hyperventilation. The type of gas was blinded from the participants for each test. EEBH durations were then recorded, as well as systolic blood pressure, SpO and heart rate. A discomfort rating was also recorded after each breath hold.
A significant increase in duration of almost 50% was observed between normal breathing of room air and breathing oxygen normally followed by hyperventilation. Vital signs remained consistent between the 4 tests. The tests were well tolerated with 75% of participants recording none or minimal discomfort.
Preoxygenation with hyperventilation could be used to increase the EEBH duration for abdominal SABR patients which would assist in the accuracy of these treatments and possibly resulting in a reduction of overall treatment times.
呼气末屏气（EEBH）是腹部立体定向消融放疗（SABR）治疗中首选的运动管理方法。然而，完成一次治疗需要多次短暂的EEBH。本研究旨在确定高通气预充氧对延长EEBH持续时间的效果。
我们将10名健康参与者随机分为两组，每组分别以每分钟10升（l/min）的速率呼吸室内空气和氧气，不进行高通气4分钟，然后正常呼吸4分钟，并以每分钟20次呼吸的速率进行1分钟高通气。每次测试时，参与者对气体类型不知情。然后记录EEBH持续时间、收缩压、血氧饱和度（SpO）和心率。每次屏气后还记录不适评分。
在呼吸室内空气正常呼吸与正常呼吸氧气后进行高通气之间，观察到持续时间显著增加近50%。四项测试之间生命体征保持一致。这些测试耐受性良好，75%的参与者记录无不适或仅有轻微不适。
高通气预充氧可用于增加腹部SABR患者的EEBH持续时间，这将有助于提高这些治疗的准确性，并可能缩短总体治疗时间。
