Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, China.
BE/Phase I Clinical Center, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361000, China.
ACS Nano. 2023 Jun 13;17(11):9826-9849. doi: 10.1021/acsnano.3c02273. Epub 2023 May 19.
The development of nanovaccines that employ polymeric delivery carriers has garnered substantial interest in therapeutic treatment of cancer and a variety of infectious diseases due to their superior biocompatibility, lower toxicity and reduced immunogenicity. Particularly, stimuli-responsive polymeric nanocarriers show great promise for delivering antigens and adjuvants to targeted immune cells, preventing antigen degradation and clearance, and increasing the uptake of specific antigen-presenting cells, thereby sustaining adaptive immune responses and improving immunotherapy for certain diseases. In this review, the most recent advances in the utilization of stimulus-responsive polymer-based nanovaccines for immunotherapeutic applications are presented. These sophisticated polymeric nanovaccines with diverse functions, aimed at therapeutic administration for disease prevention and immunotherapy, are further classified into several active domains, including pH, temperature, redox, light and ultrasound-sensitive intelligent nanodelivery systems. Finally, the potential strategies for the future design of multifunctional next-generation polymeric nanovaccines by integrating materials science with biological interface are proposed.
由于具有优越的生物相容性、较低的毒性和免疫原性，利用聚合体递送载体的纳米疫苗的发展在癌症和各种传染病的治疗方面引起了极大的关注。特别是，刺激响应性聚合体纳米载体在向靶向免疫细胞递送抗原和佐剂、防止抗原降解和清除以及增加特定抗原呈递细胞的摄取方面具有很大的应用前景，从而维持适应性免疫反应并改善某些疾病的免疫治疗。在这篇综述中，介绍了刺激响应性聚合物基纳米疫苗在免疫治疗应用中的最新进展。这些具有多种功能的复杂聚合物纳米疫苗旨在用于疾病预防和免疫治疗的治疗性给药，进一步分为几个活性领域，包括 pH、温度、氧化还原、光和超声敏感的智能纳米递药系统。最后，提出了通过将材料科学与生物界面相结合来设计多功能下一代聚合体纳米疫苗的潜在策略。
