Instituto de Investigación Biosanitaria ibs.Granada, Faculty of Health Sciences, University of Granada, Granada, Spain.
Lab Invest. 2023 Jul;103(7):100178. doi: 10.1016/j.labinv.2023.100178. Epub 2023 May 18.
The Klotho protein, known as an antiaging protein, is expressed mainly in the kidney, and kidney disorders may contribute to the disrupted expression of renal Klotho. The purpose of this systematic review was to determine if there are biological and nutraceutical therapies that increase the expression of Klotho and can help prevent complications associated with chronic kidney disease. A systematic literature review was carried out through the consultation of PubMed, Scopus, and Web of Science. Records between the years 2012 and 2022 in Spanish and English were selected. Cross-sectional or prevalence and analytical studies were included that evaluated the effects of Klotho therapy. A total of 22 studies were identified after the critical reading of these selected studies: 3 investigated the association between Klotho and growth factors, 2 evaluated the relationship between the concentration of Klotho and the type of fibrosis, 3 focused on the relationship between vascular calcifications and vitamin D, 2 assessed the relationship between Klotho and bicarbonate, 2 investigated the relationship between proteinuria and Klotho, 1 demonstrated the applicability of synthetic antibodies as a support for Klotho deficiency, 1 investigated Klotho hypermethylation as a renal biomarker, 2 investigated the relationship between proteinuria and Klotho, 4 linked Klotho as an early marker of chronic kidney disease, and 1 investigated Klotho levels in patients with autosomal dominant polycystic kidney disease. In conclusion, no study has addressed the comparison of these therapies in the context of their use with nutraceutical agents that raise the expression of Klotho.
Klotho 蛋白被称为抗衰老蛋白，主要在肾脏中表达，肾脏疾病可能导致肾脏 Klotho 的表达失调。本系统评价的目的是确定是否存在能够增加 Klotho 表达并有助于预防与慢性肾脏病相关并发症的生物和营养疗法。通过查阅 PubMed、Scopus 和 Web of Science，进行了系统的文献回顾。选择了 2012 年至 2022 年期间的西班牙语和英语记录。纳入了评估 Klotho 治疗效果的横断面或患病率和分析性研究。经过对这些选定研究的仔细阅读，共确定了 22 项研究：3 项研究了 Klotho 与生长因子之间的关系，2 项评估了 Klotho 浓度与纤维化类型之间的关系，3 项研究重点是血管钙化与维生素 D 之间的关系，2 项研究评估了 Klotho 与碳酸氢盐之间的关系，2 项研究调查了蛋白尿与 Klotho 之间的关系，1 项证明了合成抗体作为 Klotho 缺乏的支持物的适用性，1 项研究了 Klotho 高甲基化作为肾脏生物标志物，2 项研究了蛋白尿与 Klotho 之间的关系，4 项研究将 Klotho 作为慢性肾脏病的早期标志物，1 项研究了常染色体显性多囊肾病患者的 Klotho 水平。总之，没有研究比较这些疗法在与提高 Klotho 表达的营养疗法联合使用时的效果。
