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列线图预测接受骨科手术的成年患者术后手术部位感染的风险:一项回顾性研究。

A nomogram to predict postoperative surgical site infection of adult patients who received orthopaedic surgery: a retrospective study.

机构信息

Department of Orthopedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Graduate School of Peking Union Medical College, Beijing, People's Republic of China.

The School of Clinical Medicine, Fujian Medical University, The First Affiliated Hospital of Xiamen University, 55 Zhenhai Road, Xiamen, 361001, Fujian Province, People's Republic of China.

出版信息

Sci Rep. 2023 May 19;13(1):8129. doi: 10.1038/s41598-023-34926-x.

Abstract

Surgical site infection is a common postoperative complication with serious consequences. This study developed a nomogram to estimate the probability of postoperative surgical site infection for orthopaedic patients. Adult patients following orthopaedic surgery during hospitalization were included in this study. We used univariate and multivariate logistic regression analyses to establish the predictive model, which was also visualized by nomogram. To evaluate the model performance, we applied the receiver operating characteristic curve, calibration curve, and decision curve analysis, which were utilized in external validation and internal validation. From January 2021 to June 2022, a total of 787 patients were enrolled in this study. After statistical analysis, five variables were enrolled in the predictive model, including age, operation time, diabetes, WBC, and HGB. The mathematical formula has been established as follows: Logit (SSI) = - 6.301 + 1.104 * (Age) + 0.669 * (Operation time) + 2.009 * (Diabetes) + 1.520 * (WBC) - 1.119 * (HGB). The receiver Operating Characteristic curve, calibration curve, and decision curve analysis presented a good performance of this predictive model. Our nomogram showed great discriminative ability, calibration, and clinical practicability in the training set, external validation, and internal validation.

摘要

手术部位感染是一种常见的术后并发症,后果严重。本研究旨在为骨科患者建立一种预测术后手术部位感染概率的列线图。本研究纳入了住院期间接受骨科手术的成年患者。我们采用单因素和多因素逻辑回归分析来建立预测模型,并通过列线图进行可视化。为了评估模型性能,我们应用了受试者工作特征曲线、校准曲线和决策曲线分析,这些分析用于外部验证和内部验证。2021 年 1 月至 2022 年 6 月,共纳入 787 例患者。经过统计学分析,有 5 个变量被纳入预测模型,包括年龄、手术时间、糖尿病、白细胞计数和血红蛋白。数学公式如下:Logit(SSI)=-6.301+1.104*(年龄)+0.669*(手术时间)+2.009*(糖尿病)+1.520*(白细胞计数)-1.119*(血红蛋白)。受试者工作特征曲线、校准曲线和决策曲线分析表明,该预测模型具有良好的性能。我们的列线图在训练集、外部验证和内部验证中均表现出良好的判别能力、校准度和临床实用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d44a/10199048/fb5571f5ddb0/41598_2023_34926_Fig1_HTML.jpg

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