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Prevention of endotoxin-induced gastrointestinal damage by CV-3988, an antagonist of platelet-activating factor.

作者信息

Wallace J L, Whittle B J

出版信息

Eur J Pharmacol. 1986 May 13;124(1-2):209-10. doi: 10.1016/0014-2999(86)90148-2.

DOI:10.1016/0014-2999(86)90148-2
PMID:3720841
Abstract
摘要

相似文献

1
Prevention of endotoxin-induced gastrointestinal damage by CV-3988, an antagonist of platelet-activating factor.血小板活化因子拮抗剂CV-3988对内毒素诱导的胃肠道损伤的预防作用
Eur J Pharmacol. 1986 May 13;124(1-2):209-10. doi: 10.1016/0014-2999(86)90148-2.
2
Evidence for platelet-activating factor as a mediator of endotoxin-induced gastrointestinal damage in the rat. Effects of three platelet-activating factor antagonists.血小板活化因子作为大鼠内毒素诱导的胃肠道损伤介质的证据。三种血小板活化因子拮抗剂的作用。
Gastroenterology. 1987 Oct;93(4):765-73. doi: 10.1016/0016-5085(87)90438-0.
3
Is platelet activating factor (PAF) a mediator of endotoxin shock?血小板活化因子（PAF）是内毒素休克的介质吗？
Eur J Pharmacol. 1985 Feb 26;109(2):257-61. doi: 10.1016/0014-2999(85)90427-3.
4
Platelet-activating factor mediates hemodynamic changes and lung injury in endotoxin-treated rats.血小板活化因子介导内毒素处理大鼠的血流动力学变化和肺损伤。
J Clin Invest. 1987 May;79(5):1498-509. doi: 10.1172/JCI112980.
5
Effects of a platelet-activating factor antagonist, CV-3988, on different shock models in the rat.血小板活化因子拮抗剂CV - 3988对大鼠不同休克模型的影响。
Circ Shock. 1986;20(3):193-203.
6
Gastrointestinal plasma leakage in endotoxic shock. Inhibition by prostaglandin E2 and by a platelet-activating factor antagonist.内毒素休克时的胃肠道血浆渗漏。前列腺素E2和血小板活化因子拮抗剂的抑制作用。
Can J Physiol Pharmacol. 1987 Jul;65(7):1428-32. doi: 10.1139/y87-224.
7
Possible role of platelet activating factor (PAF) in disseminated intravascular coagulation (DIC), evidenced by use of a PAF antagonist, CV-3988.血小板活化因子（PAF）在弥散性血管内凝血（DIC）中的可能作用，通过使用PAF拮抗剂CV-3988得以证实。
Life Sci. 1986 Jul 14;39(2):111-7. doi: 10.1016/0024-3205(86)90444-3.
8
Characterization of the activity of a platelet activating factor antagonist, CV-3988.血小板激活因子拮抗剂CV-3988的活性表征
Jpn J Pharmacol. 1987 Jun;44(2):127-34. doi: 10.1254/jjp.44.127.
9
Suppression of phorbol myristate acetate-induced pleurisy by CV-3988, an antagonist of platelet-activating factor.血小板活化因子拮抗剂CV-3988对佛波酯诱导的胸膜炎的抑制作用
Chem Pharm Bull (Tokyo). 1986 Nov;34(11):4896-8. doi: 10.1248/cpb.34.4896.
10
A platelet-aggregating and hypotensive phospholipid isolated from bovine brain.从牛脑中分离出的一种具有血小板聚集和降血压作用的磷脂。
J Pharm Pharmacol. 1986 Dec;38(12):878-82. doi: 10.1111/j.2042-7158.1986.tb03375.x.

引用本文的文献

1
Lack of effects of acemetacin on signalling pathways for leukocyte adherence may explain its gastrointestinal safety.阿西美辛对白细胞黏附信号通路缺乏影响可能解释了其胃肠道安全性。
Br J Pharmacol. 2008 Nov;155(6):857-64. doi: 10.1038/bjp.2008.316. Epub 2008 Aug 11.
2
Increased intestinal formation of Paf in endotoxin-induced damage in the rat.大鼠内毒素诱导损伤中肠道血小板活化因子生成增加。
Br J Pharmacol. 1987 Sep;92(1):3-4. doi: 10.1111/j.1476-5381.1987.tb11287.x.
3
Failure of prostaglandin E2 and its 16,16-dimethyl analogue to prevent the gastric mucosal damage induced by Paf.
前列腺素E2及其16,16-二甲基类似物未能预防血小板活化因子诱导的胃黏膜损伤。
Br J Pharmacol. 1987 Feb;90(2):365-71. doi: 10.1111/j.1476-5381.1987.tb08966.x.
4
Indomethacin potentiates endotoxin-induced blood flow reduction and histological injury in rat gastric mucosa.吲哚美辛可增强内毒素诱导的大鼠胃黏膜血流减少和组织学损伤。
Br J Pharmacol. 1988 Apr;93(4):925-31. doi: 10.1111/j.1476-5381.1988.tb11481.x.
5
Gastric mucosal damage induced by local intra-arterial administration of Paf in the rat.局部动脉内注射血小板活化因子（PAF）诱导大鼠胃黏膜损伤。
Br J Pharmacol. 1988 Jan;93(1):222-8. doi: 10.1111/j.1476-5381.1988.tb11425.x.
6
Gastrointestinal damage induced by platelet-activating factor. Inhibition by the corticoid, dexamethasone.血小板活化因子诱导的胃肠道损伤。皮质类固醇地塞米松的抑制作用。
Dig Dis Sci. 1988 Feb;33(2):225-32. doi: 10.1007/BF01535737.
7
Effects of inhibitors of arachidonic acid metabolism on Paf-induced gastric mucosal necrosis and haemoconcentration.花生四烯酸代谢抑制剂对血小板活化因子诱导的胃黏膜坏死和血液浓缩的影响。
Br J Pharmacol. 1986 Oct;89(2):415-22. doi: 10.1111/j.1476-5381.1986.tb10275.x.
8
Biosynthesis of platelet-activating factor in glandular gastric mucosa. Evidence for the involvement of the 'de novo' pathway and modulation by fatty acids.腺胃黏膜中血小板活化因子的生物合成。“从头合成”途径参与及脂肪酸调节的证据。
Biochem J. 1988 Sep 15;254(3):707-14. doi: 10.1042/bj2540707.
9
The potential pathophysiological role of platelet-activating factor in human diseases.
Klin Wochenschr. 1988 May 2;66(9):373-8. doi: 10.1007/BF01737939.
10
Castor oil increases intestinal formation of platelet-activating factor and acid phosphatase release in the rat.蓖麻油可增加大鼠肠道中血小板活化因子的生成及酸性磷酸酶的释放。
Br J Pharmacol. 1989 Apr;96(4):872-4. doi: 10.1111/j.1476-5381.1989.tb11897.x.