大鼠内毒素诱导损伤中肠道血小板活化因子生成增加。
Increased intestinal formation of Paf in endotoxin-induced damage in the rat.
作者信息
Whittle B J, Boughton-Smith N K, Hutcheson I R, Esplugues J V, Wallace J L
机构信息
Department of Mediator Pharmacology, Wellcome Research Laboratories, Beckenham, Kent.
出版信息
Br J Pharmacol. 1987 Sep;92(1):3-4. doi: 10.1111/j.1476-5381.1987.tb11287.x.
Abstract
Platelet-activating factor (Paf) has been proposed as a mediator of the gastrointestinal damage in endotoxic shock. The formation of Paf in rat jejunal tissue, determined following extraction and bioassay on rabbit washed platelets has therefore been correlated with the induction of damage following endotoxin administration. Intravenous injection of E. coli endotoxin led to a time-dependent increase in the jejunal formation of Paf, which after 20 min was twenty fold greater than the control level. There was a significant correlation between elevated Paf release and intestinal hyperaemia and haemorrhage, thus supporting a role for Paf as a mediator of such damage.
摘要
血小板活化因子（PAF）被认为是内毒素休克时胃肠道损伤的介质。因此，通过对兔洗涤血小板进行提取和生物测定来确定大鼠空肠组织中PAF的形成，已与内毒素给药后损伤的诱导相关联。静脉注射大肠杆菌内毒素导致空肠PAF形成呈时间依赖性增加，20分钟后比对照水平高20倍。PAF释放升高与肠道充血和出血之间存在显著相关性，从而支持PAF作为这种损伤介质的作用。
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本文引用的文献
1
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Thromb Res. 1983 May 15;30(4):383-9. doi: 10.1016/0049-3848(83)90230-x.
2
Synthesis of PAF-acether and blood volume changes in gram-negative sepsis.革兰氏阴性菌败血症中血小板活化因子 - 乙酰醚的合成与血容量变化
Immunopharmacology. 1985 Feb;9(1):45-52. doi: 10.1016/0162-3109(85)90046-3.
3
Hydrocortisone and 'macrocortin' inhibit the zymosan-induced release of lyso-PAF from rat peritoneal leucocytes.氢化可的松和“大皮质素”可抑制酵母聚糖诱导的大鼠腹腔白细胞中溶血血小板活化因子的释放。
Life Sci. 1985 Apr 1;36(13):1225-31. doi: 10.1016/0024-3205(85)90266-8.
4
Microvascular actions of platelet-activating factor on rat gastric mucosa and submucosa.血小板活化因子对大鼠胃黏膜和黏膜下层的微血管作用。
Am J Physiol. 1986 Dec;251(6 Pt 1):G772-8. doi: 10.1152/ajpgi.1986.251.6.G772.
5
Profile of gastrointestinal damage induced by platelet-activating factor.血小板活化因子诱导的胃肠道损伤概况
Prostaglandins. 1986 Jul;32(1):137-41. doi: 10.1016/0090-6980(86)90156-5.
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Prevention of endotoxin-induced gastrointestinal damage by CV-3988, an antagonist of platelet-activating factor.血小板活化因子拮抗剂CV-3988对内毒素诱导的胃肠道损伤的预防作用
Eur J Pharmacol. 1986 May 13;124(1-2):209-10. doi: 10.1016/0014-2999(86)90148-2.
7
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