Reproductive Epidemiology Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, P.O. Box: 16635-148, Iran.
Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Reprod Biol Endocrinol. 2023 May 19;21(1):48. doi: 10.1186/s12958-022-01034-w.
Subfertility in obese and diabetic men during the reproductive age is evident, but the mechanisms by which obesity and diabetes mellitus cause male infertility are not entirely understood. The current study aimed to evaluate the effects and potential mechanisms of obesity and diabetes on male fertility.
We enrolled control = 40, obese = 40, Lean-DM = 35, and Obese-DM = 35 individuals. The obesity-associated markers, diabetic markers, hormonal and lipid profile, inflammatory indices, and semen analysis were assessed in four experimental groups.
Our finding showed that diabetic markers were significantly increased in two diabetic groups, while obesity indices were markedly increased in two obese groups. Conventional sperm parameters were significantly lower in three groups compared with the control. Serum levels of total testosterone and sex hormone-binding globulin were significantly lower in men with obesity and DM compared with the control. There was a significant difference in the concentration of high-sensitivity C-reactive protein among four experimental groups. Moreover, serum leptin was significantly increased in obese DM, lean DM, and obese groups. Serum insulin levels had a positive correlation with metabolic-associated indices and high-sensitivity C-reactive protein levels, whereas it had a negative correlation with count, motility, and morphology.
Our findings showed the metabolic changes, hormonal dysfunction and inflammatory disturbance might be suspected mechanisms of subfertility in obese and diabetic subfertile men.
肥胖和糖尿病患者在生殖年龄的生育能力下降是明显的，但肥胖和糖尿病导致男性不育的机制尚不完全清楚。本研究旨在评估肥胖和糖尿病对男性生育能力的影响及其潜在机制。
我们纳入了 40 名对照组、40 名肥胖组、35 名 Lean-DM 组和 35 名 Obese-DM 组。在四个实验组中评估了肥胖相关标志物、糖尿病标志物、激素和脂质谱、炎症指标和精液分析。
我们的研究结果表明，两个糖尿病组的糖尿病标志物显著升高，而两个肥胖组的肥胖指数显著升高。与对照组相比，三组的常规精子参数明显降低。与对照组相比，肥胖和糖尿病患者的血清总睾酮和性激素结合球蛋白水平显著降低。四个实验组之间的高敏 C 反应蛋白浓度存在显著差异。此外，肥胖 DM、Lean-DM 和肥胖组的血清瘦素水平显著升高。血清胰岛素水平与代谢相关指标和高敏 C 反应蛋白水平呈正相关，而与计数、活力和形态呈负相关。
我们的研究结果表明，代谢变化、激素功能障碍和炎症紊乱可能是肥胖和糖尿病男性生育能力下降的潜在机制。
