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鸢尾素通过促进牙周膜的成骨潜能来减少大鼠正畸牙齿移动。

Irisin reduces orthodontic tooth movement in rats by promoting the osteogenic potential in the periodontal ligament.

机构信息

Department of Biomaterials, Faculty of Dentistry, University of Oslo, Oslo, Norway.

Department of Orthodontics, Faculty of Dentistry, University of Oslo, Oslo, Norway.

出版信息

Eur J Orthod. 2023 Nov 30;45(6):842-853. doi: 10.1093/ejo/cjad021.

DOI:10.1093/ejo/cjad021
PMID:37209709
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10687601/
Abstract

OBJECTIVES

Positive effects of irisin on osteogenic differentiation of periodontal ligament (PDL) cells have been identified previously, this study aims to examine its effect on orthodontic tooth movement (OTM) in vivo.

MATERIALS AND METHODS

The maxillary right first molars of male Wistar rats (n = 21) were moved mesially for 14 days, with submucosal injection of two dosages of irisin (0.1 or 1 μg) or phosphate-buffered saline (control) every third day. OTM was recorded by feeler gauge and micro-computed tomography (μCT). Alveolar bone and root volume were analysed using μCT, and plasma irisin levels by ELISA. Histological characteristics of PDL tissues were examined, and the expression of collagen type I, periostin, osteocalcin (OCN), von Willebrand factor (vWF) and fibronectin type III domain-containing protein 5 (FNDC5) in PDL was evaluated by immunofluorescence staining.

RESULTS

Repeated 1 μg irisin injections suppressed OTM on days 6, 9, and 12. No significant differences were observed in OTM in the 0.1 μg irisin group, or in bone morphometric parameters, root volume or plasma irisin, compared to control. Resorption lacunae and hyalinization were found at the PDL-bone interface on the compression side in the control, whereas they were scarce after irisin administration. The expression of collagen type I, periostin, OCN, vWF, and FNDC5 in PDL was enhanced by irisin administration.

LIMITATIONS

The feeler gauge method may overestimate OTM.

CONCLUSIONS

Submucosal irisin injection reduced OTM by enhancing osteogenic potential of PDL, and this effect was more significant on the compression side.

摘要

目的

先前已经证实鸢尾素对牙周韧带（PDL）细胞成骨分化具有积极影响，本研究旨在体内研究其对正畸牙齿移动（OTM）的作用。

材料和方法

雄性 Wistar 大鼠（n = 21）的上颌右侧第一磨牙向近中移动 14 天，每隔三天通过黏膜下注射两种剂量的鸢尾素（0.1 或 1 μg）或磷酸盐缓冲盐水（对照）。通过测隙规和微计算机断层扫描（μCT）记录 OTM。使用 μCT 分析牙槽骨和根体积，并通过 ELISA 分析血浆鸢尾素水平。通过免疫荧光染色检测 PDL 组织的组织学特征，并评估 PDL 中Ⅰ型胶原、骨膜蛋白、骨钙素（OCN）、血管性血友病因子（vWF）和纤维连接蛋白 III 结构域包含蛋白 5（FNDC5）的表达。

结果

重复注射 1 μg 鸢尾素可抑制第 6、9 和 12 天的 OTM。与对照组相比，0.1 μg 鸢尾素组的 OTM 或骨形态计量学参数、根体积或血浆鸢尾素均无明显差异。在对照组中，在骨-PDL 界面的压缩侧发现吸收陷窝和玻璃样变，而在鸢尾素给药后则很少见。鸢尾素给药后 PDL 中Ⅰ型胶原、骨膜蛋白、OCN、vWF 和 FNDC5 的表达增强。

局限性

测隙规法可能会高估 OTM。

结论

黏膜下注射鸢尾素通过增强 PDL 的成骨潜能来减少 OTM，在压缩侧的效果更为显著。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d3/10687601/6256f0282b78/cjad021_fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d3/10687601/ed0d17420a18/cjad021_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d3/10687601/1c7d41df6852/cjad021_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d3/10687601/99abaad6a498/cjad021_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d3/10687601/8c50fd288039/cjad021_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d3/10687601/5c7357854393/cjad021_fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d3/10687601/667d02f40748/cjad021_fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d3/10687601/1bbce0a9ce9f/cjad021_fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d3/10687601/4e1951babb99/cjad021_fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d3/10687601/6256f0282b78/cjad021_fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d3/10687601/ed0d17420a18/cjad021_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d3/10687601/1c7d41df6852/cjad021_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d3/10687601/99abaad6a498/cjad021_fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d3/10687601/8c50fd288039/cjad021_fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d3/10687601/5c7357854393/cjad021_fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d3/10687601/667d02f40748/cjad021_fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d3/10687601/1bbce0a9ce9f/cjad021_fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d3/10687601/4e1951babb99/cjad021_fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20d3/10687601/6256f0282b78/cjad021_fig9.jpg

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Immune System Acts on Orthodontic Tooth Movement: Cellular and Molecular Mechanisms.免疫系统在正畸牙齿移动中的作用：细胞和分子机制。
Biomed Res Int. 2022 Oct 25;2022:9668610. doi: 10.1155/2022/9668610. eCollection 2022.
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Irisin attenuates P. gingivalis-suppressed osteogenic/cementogenic differentiation of periodontal ligament cells via p38 signaling pathway.
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Biochem Biophys Res Commun. 2022 Aug 27;618:100-106. doi: 10.1016/j.bbrc.2022.06.001. Epub 2022 Jun 7.
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Irisin effects on bone: systematic review with meta-analysis of preclinical studies and prospects for oral health.鸢尾素对骨骼的影响：临床前研究的系统评价与荟萃分析及口腔健康前景
Braz Oral Res. 2022 Apr 15;36:e055. doi: 10.1590/1807-3107bor-2022.vol36.0055. eCollection 2022.
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