细胞电耦合：电场塑造神经活动并“调整”大脑的基础结构。
Cytoelectric coupling: Electric fields sculpt neural activity and "tune" the brain's infrastructure.
机构信息
Centre for Mathematical Neuroscience and Psychology and Department of Psychology, City -University of London, London EC1V 0HB, United Kingdom; The Picower Institute for Learning & Memory and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Departments of Otolaryngology, Biomedical Engineering, and Electrical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA.
出版信息
Prog Neurobiol. 2023 Jul;226:102465. doi: 10.1016/j.pneurobio.2023.102465. Epub 2023 May 18.
We propose and present converging evidence for the Cytoelectric Coupling Hypothesis: Electric fields generated by neurons are causal down to the level of the cytoskeleton. This could be achieved via electrodiffusion and mechanotransduction and exchanges between electrical, potential and chemical energy. Ephaptic coupling organizes neural activity, forming neural ensembles at the macroscale level. This information propagates to the neuron level, affecting spiking, and down to molecular level to stabilize the cytoskeleton, "tuning" it to process information more efficiently.
我们提出并呈现了细胞电耦合假说的汇聚证据
神经元产生的电场可以一直延伸到细胞骨架的水平，这可以通过电泳扩散和机械转导以及电、势和化学能之间的交换来实现。电突触耦合组织神经活动，在宏观水平上形成神经集合体。这些信息传播到神经元水平，影响神经元的发放，一直到分子水平稳定细胞骨架，“调整”其以更有效地处理信息。
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