Rolly G, Poelaert J, Mungroop H, Paelinck H
J Int Med Res. 1986;14(3):148-52. doi: 10.1177/030006058601400306.
Sixty patients suffering from moderate to severe pain following either orthopaedic or gynaecological surgery were treated with intramuscular buprenorphine (0.3 mg) or an intramuscular combination of buprenorphine (0.3 mg)/naloxone (0.2 mg) and the analgesic efficacy and safety of the two treatments was compared. The evaluation of efficacy showed that both treatments provided good analgesia which was apparent at the first assessment time (10 minutes) and continued for approximately 10 hours. Only seven patients suffered from unwanted side-effects with only drowsiness/sleepiness and nausea being reported by more than one patient. Over-all analysis of the results showed that there were no significant differences between the two treatments with regard to efficacy and safety.
60名因骨科或妇科手术后出现中度至重度疼痛的患者接受了肌肉注射丁丙诺啡（0.3毫克）或丁丙诺啡（0.3毫克）/纳洛酮（0.2毫克）的肌肉注射联合治疗，并比较了两种治疗方法的镇痛效果和安全性。疗效评估显示，两种治疗方法均提供了良好的镇痛效果，在首次评估时间（10分钟）时即明显起效，并持续约10小时。只有7名患者出现了不良反应，报告超过1例的只有嗜睡/困倦和恶心。结果的总体分析表明，两种治疗方法在疗效和安全性方面没有显著差异。
