Department of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, Italy.
Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Cell Calcium. 2023 Jul;113:102759. doi: 10.1016/j.ceca.2023.102759. Epub 2023 May 19.
Multiple forms of regulated cell death (RCD) have been characterized, each of which originates from the activation of a dedicated molecular machinery. RCD can occur in purely physiological settings or upon failing cellular adaptation to stress. Caions have been shown to physically interact with - and hence regulate - various components of the RCD machinery. Moreover, intracellular Ca accumulation can promote organellar dysfunction to degree that can be overtly cytotoxic or sensitize cells to RCD elicited by other stressors. Here, we provide an overview of the main links between Caand different forms of RCD, including apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, lysosome-dependent cell death, and parthanatos.
已经鉴定出多种形式的调节性细胞死亡（RCD），每种形式都源自特定分子机制的激活。RCD 可以在纯生理环境中发生，也可以在细胞适应应激失败时发生。钙已经被证明可以与 RCD 机制的各种成分相互作用并调节它们。此外，细胞内钙积累会促进细胞器功能障碍，从而导致明显的细胞毒性，或使细胞对其他应激源引发的 RCD 敏感。在这里，我们提供了钙与不同形式的 RCD（包括细胞凋亡、线粒体通透性转换（MPT）驱动的坏死、坏死性凋亡、铁死亡、溶酶体依赖性细胞死亡和 Parthanatos）之间的主要联系的概述。
