Thymus Biology Section, Experimental Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda 20892, United States.
Curr Opin Immunol. 2023 Aug;83:102336. doi: 10.1016/j.coi.2023.102336. Epub 2023 May 19.
The thymoproteasome is a type of proteasome expressed specifically in thymic cortical epithelial cells. Thymoproteasome affects antigen processing of major histocompatibility complex (MHC)-I-associated peptides and optimizes positive selection of CD8 T cells. However, it remains unanswered whether and how thymoproteasome-dependent MHC-I-associated self-peptides contribute to positive selection of cortical thymocytes. This short piece discusses the potential mechanisms of thymoproteasome contribution to positive selection of MHC-I-restricted CD8 T cells.
胸腺蛋白酶体是一种在胸腺皮质上皮细胞中特异性表达的蛋白酶体。胸腺蛋白酶体影响主要组织相容性复合体 (MHC)-I 相关肽的抗原加工，并优化 CD8 T 细胞的阳性选择。然而，胸腺蛋白酶体依赖性 MHC-I 相关自身肽是否以及如何有助于皮质胸腺细胞的阳性选择仍未得到解答。本文讨论了胸腺蛋白酶体对 MHC-I 限制性 CD8 T 细胞阳性选择的潜在贡献机制。
