Department of Public Health and Community Medicine, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA 02111, United States of America.
Department of Geography, Ohio State University, 154 North Oval Mall, Columbus, OH 43210, United States of America.
J Subst Use Addict Treat. 2023 Jul;150:209077. doi: 10.1016/j.josat.2023.209077. Epub 2023 May 19.
The opioid overdose epidemic continues to impact a large swath of the population in the US. Medications for opioid use disorders (MOUD) are an effective resource to combat the epidemic; however, there is limited research on MOUD treatment access that accounts for both supply of and demand for services. We aimed to examine access to buprenorphine prescribers in the HEALing Communities Study (HCS) Wave 2 communities in Massachusetts, Ohio, and Kentucky during 2021, and the association between buprenorphine access and opioid-related incidents, specifically fatal overdoses and opioid-related responses by emergency medical services (EMS).
We calculated Enhanced 2-Step Floating Catchment Area (E2SFCA) accessibility indices for each state, as well as Wave 2 communities in each state, based on the location of providers (buprenorphine-waivered clinicians from the US Drug Enforcement Agency Active Registrants database), population-weighted centroids at the census block group level, and catchment areas defined by the state or community's average commute time. In advance of intervention initiation, we quantified the opioid-related risk environment of communities. We assessed gaps in services by using bivariate Local Moran's I analysis, incorporating accessibility indices and opioid-related incident data.
Massachusetts Wave 2 HCS communities had the highest rates of buprenorphine prescribers per 1000 patients (median: 165.8) compared to Kentucky (38.8) and Ohio (40.1). While urban centers in all three states had higher E2SFCA index scores compared to rural communities, we observed that suburban communities often had limited access. Through bivariate Local Moran's I analysis, we identified numerous locations with low buprenorphine access surrounded by high opioid-related incidents, particularly in communities that surrounded Boston, Massachusetts; Columbus, Ohio; and Louisville, Kentucky.
Rural communities demonstrated a great need for additional access to buprenorphine prescribers. However, policymakers should also direct attention toward suburban communities that have experienced significant increases in opioid-related incidents.
阿片类药物过量的流行在美国仍在很大程度上影响着许多人。阿片类药物使用障碍的药物(MOUD)是对抗这一流行的有效资源;然而,关于 MOUD 治疗可及性的研究有限,这些研究既考虑了服务的供应,也考虑了服务的需求。我们的目的是在马萨诸塞州、俄亥俄州和肯塔基州的 HEALing 社区研究(HCS)第 2 波社区中,检查 2021 年丁丙诺啡处方医生的可及性,并调查丁丙诺啡可及性与阿片类药物相关事件之间的关系,特别是致命的过量用药和紧急医疗服务(EMS)的阿片类药物相关反应。
我们根据提供者的位置(美国毒品管制局活跃登记册中的丁丙诺啡豁免临床医生)、按人口加权的普查块组级别的重心以及由州或社区平均通勤时间定义的集水区,为每个州以及每个州的第 2 波社区计算了增强型两步浮动集水区(E2SFCA)可及性指数。在干预启动之前,我们量化了社区的阿片类药物相关风险环境。我们通过使用双变量局部 Moran's I 分析来评估服务差距,该分析结合了可及性指数和阿片类药物相关事件数据。
马萨诸塞州 HCS 第 2 波社区每 1000 名患者的丁丙诺啡处方医生人数最多(中位数:165.8),而肯塔基州(38.8)和俄亥俄州(40.1)则较少。虽然这三个州的城市中心的 E2SFCA 指数得分都高于农村社区,但我们发现郊区社区的可及性往往较低。通过双变量局部 Moran's I 分析,我们发现许多低丁丙诺啡可及性的地点周围都有高阿片类药物相关事件,尤其是在马萨诸塞州波士顿周围、俄亥俄州哥伦布市和肯塔基州路易斯维尔市周围的社区。
农村社区对增加丁丙诺啡处方医生的需求很大。然而,政策制定者也应将注意力转向经历阿片类药物相关事件显著增加的郊区社区。