Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Phytother Res. 2023 Aug;37(8):3275-3295. doi: 10.1002/ptr.7894. Epub 2023 May 21.
Radiodermatitis in breast cancer patients varies from mild irritation to life-threatening lesions. Several studies suggest a role for topical corticosteroid ointments in the treatment of radiodermatitis. Yet, to avoid the adverse effects of corticosteroids, many authors recommend the use of topical herbal products instead. The therapeutic role of herbal treatments has yet to be fully understood. This systematic review evaluates the role of topical or oral herbal medicines in radiodermatitis prevention and treatment. A systematic search of four databases (Embase, PubMed, Web of Science, and Scopus) was performed without language and time restrictions from their inception until April 2023. The bibliographies of potential articles were also searched manually. Studies evaluated and compared the effects of herbal preparations with the control group, on dermatitis induced by radiotherapy for breast cancer. The Cochrane risk of bias tool was used to assess the included studies. Thirty-five studies were included in the systematic review. Studies which used herbal drugs including topical and oral formulations were evaluated. Herbal monotherapy and combination therapy were reported, and their effects on radiodermatitis were explained in the systematic review. In conclusion, henna ointments, silymarin gel, and Juango cream were reported to reduce the severity of radiodermatitis. These agents should be considered for radiodermatitis prophylaxis and treatment. The data on aloe gel and calendula ointment were conflicting. Further randomized controlled trials of herbal medications and new herbal formulations are required to determine their effects on breast cancer radiodermatitis.
放射性皮炎在乳腺癌患者中从轻度刺激到危及生命的病变不等。几项研究表明，局部皮质类固醇软膏在放射性皮炎的治疗中有一定作用。然而，为了避免皮质类固醇的不良反应，许多作者建议使用局部草药产品。草药治疗的治疗作用尚未得到充分理解。本系统评价评估了局部或口服草药药物在放射性皮炎预防和治疗中的作用。在没有语言和时间限制的情况下，从数据库（Embase、PubMed、Web of Science 和 Scopus）中进行了系统搜索，检索时间从数据库建立到 2023 年 4 月。还手动搜索了潜在文章的参考文献。研究评估并比较了草药制剂与对照组在乳腺癌放射治疗引起的皮炎方面的效果。使用 Cochrane 偏倚风险工具评估纳入的研究。系统评价纳入了 35 项研究。评估了使用草药药物（包括局部和口服制剂）的研究。报告了草药单药治疗和联合治疗，并在系统评价中解释了它们对放射性皮炎的影响。结论是，指甲花软膏、水飞蓟素凝胶和 Juango 霜被报道可减轻放射性皮炎的严重程度。这些药物应考虑用于放射性皮炎的预防和治疗。关于芦荟凝胶和金盏花软膏的数据相互矛盾。需要进一步的随机对照试验来确定草药药物和新的草药制剂对乳腺癌放射性皮炎的影响。
