Department of Internal Medicine, University of California, San Francisco, Fresno, CA 93701, United States.
Department of Hepatology, Liver Institute Northwest, Seattle, WA 98105, United States.
World J Gastroenterol. 2023 May 7;29(17):2551-2570. doi: 10.3748/wjg.v29.i17.2551.
Alcohol-related hepatitis (ARH) is a unique type of alcohol-associated liver disease characterized by acute liver inflammation caused by significant alcohol use. It ranges in severity from mild to severe and carries significant morbidity and mortality. The refinement of scoring systems has enhanced prognostication and guidance of clinical decision-making in the treatment of this complex disease. Although treatment focuses on supportive care, steroids have shown benefit in select circumstances. There has been a recent interest in this disease process, as coronavirus disease 2019 pandemic led to substantial rise in cases. Although much is known regarding the pathogenesis, prognosis remains grim due to limited treatment options. This article summarizes the epidemiology, genetics, pathogenesis, diagnosis and treatment of ARH.
酒精性肝炎(ARH)是一种独特的与酒精相关的肝病类型,其特征是由于大量饮酒引起的急性肝炎症。其严重程度从轻到重不等,具有较高的发病率和死亡率。评分系统的完善提高了对这种复杂疾病治疗的预后预测和临床决策指导。虽然治疗重点是支持性护理,但在某些情况下类固醇显示出了益处。由于治疗选择有限,这种疾病过程最近引起了人们的关注,因为 2019 年冠状病毒病大流行导致病例大量增加。尽管对于发病机制已经有了很多了解,但由于治疗选择有限,预后仍然很严峻。本文总结了 ARH 的流行病学、遗传学、发病机制、诊断和治疗。