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酒精性肝炎：一篇综述文章。

Alcohol-related hepatitis: A review article.

机构信息

Department of Internal Medicine, University of California, San Francisco, Fresno, CA 93701, United States.

Department of Hepatology, Liver Institute Northwest, Seattle, WA 98105, United States.

出版信息

World J Gastroenterol. 2023 May 7;29(17):2551-2570. doi: 10.3748/wjg.v29.i17.2551.

DOI:10.3748/wjg.v29.i17.2551
PMID:37213401
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10198060/
Abstract

Alcohol-related hepatitis (ARH) is a unique type of alcohol-associated liver disease characterized by acute liver inflammation caused by significant alcohol use. It ranges in severity from mild to severe and carries significant morbidity and mortality. The refinement of scoring systems has enhanced prognostication and guidance of clinical decision-making in the treatment of this complex disease. Although treatment focuses on supportive care, steroids have shown benefit in select circumstances. There has been a recent interest in this disease process, as coronavirus disease 2019 pandemic led to substantial rise in cases. Although much is known regarding the pathogenesis, prognosis remains grim due to limited treatment options. This article summarizes the epidemiology, genetics, pathogenesis, diagnosis and treatment of ARH.

摘要

酒精性肝炎（ARH）是一种独特的与酒精相关的肝病类型，其特征是由于大量饮酒引起的急性肝炎症。其严重程度从轻到重不等，具有较高的发病率和死亡率。评分系统的完善提高了对这种复杂疾病治疗的预后预测和临床决策指导。虽然治疗重点是支持性护理，但在某些情况下类固醇显示出了益处。由于治疗选择有限，这种疾病过程最近引起了人们的关注，因为 2019 年冠状病毒病大流行导致病例大量增加。尽管对于发病机制已经有了很多了解，但由于治疗选择有限，预后仍然很严峻。本文总结了 ARH 的流行病学、遗传学、发病机制、诊断和治疗。

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JGH Open. 2023 Jan 13;7(2):148-151. doi: 10.1002/jgh3.12864. eCollection 2023 Feb.
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Ten-year trends and prediction model of 30-day inpatient mortality for alcoholic hepatitis in the United States.美国酒精性肝炎患者30天住院死亡率的十年趋势及预测模型
Ann Gastroenterol. 2022 Jul-Aug;35(4):427-433. doi: 10.20524/aog.2022.0718. Epub 2022 May 12.
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Seasonal Variations of Hospital Admissions for Alcohol-Related Hepatitis in the United States.
J Microbiol Biotechnol. 2024 Oct 28;34(10):2100-2111. doi: 10.4014/jmb.2407.07051. Epub 2024 Aug 9.
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The Diagnostic Value of Liver Biopsy for Unexplained Liver Dysfunction: A Retrospective Study.肝活检对不明原因肝功能障碍的诊断价值：一项回顾性研究。
J Multidiscip Healthc. 2024 May 17;17:2399-2407. doi: 10.2147/JMDH.S460338. eCollection 2024.
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Proteomics identifies complement protein signatures in patients with alcohol-associated hepatitis.蛋白质组学鉴定出酒精相关性肝炎患者的补体蛋白特征。
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Front Med (Lausanne). 2023 Nov 28;10:1290266. doi: 10.3389/fmed.2023.1290266. eCollection 2023.
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