Cao Xuejie, Yuan Lichao
Genoxor Medical Science and Technology Inc., Shanghai, China.
Department of Infectious Disease, China-Japan Friendship Hospital, No. 2, Yinghuayuan East Street, Chaoyang, Beijing 100010, China.
Open Life Sci. 2023 May 18;18(1):20220599. doi: 10.1515/biol-2022-0599. eCollection 2023.
Infective endocarditis (IE) caused by is rare. Consequently, little is known about the natural course of endocarditis caused by this pathogen. This report describes the case of a 37-year-old male patient with endocarditis. The patient was hospitalized for a fever of unknown origin. He complained of intermittent fever of unknown origin for 2 months. He had also undergone root canal therapy for pulpitis a month ago. After admission, the infectious pathogen was identified using metagenomic next-generation sequence technology. The anaerobic blood culture bottle showed only Gram-positive cocci. Transthoracic echocardiography showed 10 mm vegetation on the aorta, which met the IE diagnostic Duke's criteria, and the patient was diagnosed with IE. Because no bacterial colonies were formed on the culture, the drug sensitivity test could not be conducted. Ceftriaxone anti-infective drugs are based on careful consideration of the literature and patient. Six days after antibiotic treatment in our department, the patient was discharged from the hospital in stable condition and had no adverse reactions at 1 week of follow-up. To help clinicians better understand the disease of IE, we also reviewed and discussed the relevant cases published after 2010 when presenting the report.
由[病原体名称未给出]引起的感染性心内膜炎（IE）较为罕见。因此，对于由该病原体引起的心内膜炎的自然病程知之甚少。本报告描述了一名37岁男性感染性心内膜炎患者的病例。该患者因不明原因发热入院。他主诉不明原因间歇性发热2个月。1个月前他还因牙髓炎接受了根管治疗。入院后，使用宏基因组下一代测序技术鉴定出感染病原体[病原体名称未给出]。厌氧血培养瓶仅显示革兰氏阳性球菌。经胸超声心动图显示主动脉上有10毫米的赘生物，符合IE诊断的杜克标准，该患者被诊断为[病原体名称未给出]IE。由于培养未形成细菌菌落，无法进行药敏试验。基于对文献和患者的仔细考虑，使用头孢曲松抗感染药物。在我科进行抗生素治疗6天后，患者病情稳定出院，随访1周无不良反应。为帮助临床医生更好地了解[病原体名称未给出]IE疾病，我们在报告时还回顾并讨论了2010年后发表的相关病例。
