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1例麻疹孪生球菌引起的多瓣膜心内膜炎

A Case of Gemella morbillorum Causing Multi-valvular Endocarditis.

作者信息

Panama Gabriel, Martinez Adolfo, Yavari Majid, Geunwon Kim Andrew, Abela George

机构信息

Department of Internal Medicine, Michigan State University, East Lansing, USA.

Department of Cardiology, Michigan State University, East Lansing, USA.

出版信息

Cureus. 2024 Feb 6;16(2):e53716. doi: 10.7759/cureus.53716. eCollection 2024 Feb.

Abstract

This is the case of a 31-year-old man with no significant past medical history who presented to the emergency department experiencing persistent fevers, chills, and malaise for the past 2-3 weeks. During this period, he had multiple urgent care visits for possible left-sided otitis media which was treated with short a course of Augmentin. While on antibiotics his symptoms would improve, but they would reappear once he had finished treatment. The patient also had significant dental carries with a chronic right molar infection. At the emergency department, blood cultures grew two out of two. Transthoracic echocardiography showed a 1 cm x 0.5 cm mobile density on the left coronary cusp of the aortic valve with moderate-severe aortic insufficiency. The patient was started on empiric IV vancomycin. Further workup revealed that the source of infection was dental carries. While proceeding with a transesophageal echocardiogram, the patient went into flash pulmonary edema requiring ICU admission. Imaging revealed an elongated 1.7 cm x 0.6 cm vegetation attached to the base of the left coronary cusp on the left ventricular outflow tract side with severe aortic regurgitation and a small 0.8 cm x 0.8 cm vegetation on the atrial side of the anterior mitral leaflet at A2 associated with mitral leaflet perforation with severe mitral regurgitation. Oral surgery removed the infected teeth. Cardiothoracic surgery performed open heart valve replacement which revealed a completely destroyed aortic valve, droplet vegetation, and destruction of the mitral valve leading to mechanical valve replacement. The patient received a two-week course of gentamycin while in the ICU with meropenem. Once sensitivities were back, he was switched to IV penicillin therapy for a total of six weeks.

摘要

这是一名31岁男性的病例,他既往无重大病史,因在过去2至3周持续发热、寒战和全身不适而就诊于急诊科。在此期间,他因可能的左侧中耳炎多次前往紧急护理中心就诊,接受了短期的阿莫西林克拉维酸钾治疗。在使用抗生素期间,他的症状会有所改善,但治疗结束后症状会再次出现。该患者还患有严重的龋齿,并伴有慢性右磨牙感染。在急诊科,血培养两次均呈阳性。经胸超声心动图显示主动脉瓣左冠状动脉瓣叶上有一个1厘米×0.5厘米的活动致密影,伴有中度至重度主动脉瓣关闭不全。患者开始接受经验性静脉注射万古霉素治疗。进一步检查发现感染源是龋齿。在进行经食管超声心动图检查时,患者出现急性肺水肿,需要入住重症监护病房。影像学检查显示,在左心室流出道一侧的左冠状动脉瓣叶基部附着有一个细长的1.7厘米×0.6厘米的赘生物,伴有严重的主动脉瓣反流,在前叶二尖瓣A2处的心房侧有一个小的0.8厘米×0.8厘米的赘生物,伴有二尖瓣叶穿孔和严重的二尖瓣反流。口腔外科手术拔除了感染的牙齿。心胸外科进行了心脏瓣膜置换术,结果显示主动脉瓣完全毁损、散在性赘生物以及二尖瓣毁损,最终进行了机械瓣膜置换。患者在重症监护病房接受了为期两周的庆大霉素联合美罗培南治疗。药敏结果出来后,他改为静脉注射青霉素治疗,总共持续六周。

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