Centro de Investigação Interdisciplinar Egas Moniz, Instituto Universitário Egas Moniz, Campus Universitário, Quinta da Granja, Monte de Caparica, 2829-511 Caparica, Portugal.
School of Natural Sciences, University of Central Lancashire, Preston PR1 2HE, UK.
Nutrients. 2022 Jul 5;14(13):2773. doi: 10.3390/nu14132773.
The scientific evidence that cinnamon may exert beneficial effects on type 2 diabetes mellitus due to the biological activity of its bioactive compounds has been increasing in recent years. This review provides an overview of the effects of cinnamon on clinical parameters of diabetes and summarizes the molecular mechanisms of action of cinnamon on glucose and lipid metabolism. Search criteria include an electronic search using PubMed, Medline, and Cochrane Library databases. English literature references from 2000 up to 2022 were included. Following title and abstract review, full articles that met the inclusion criteria were included. The results from the available evidence revealed that cinnamon improved glycemic and lipidemic indicators. Clinical trials clarified that cinnamon also possesses an anti-inflammatory effect, which may act beneficially in diabetes. Based on and studies, cinnamon seems to elicit the regulation of glucose metabolism in tissues by insulin-mimetic effect and enzyme activity improvement. Furthermore, cinnamon seems to decrease cholesterol and fatty acid absorption in the gut. The current literature search showed a considerable number of studies on diabetic subjects. Some limitations in comparing published data should be highlighted, including variability in doses, extracts and species of cinnamon, administration forms, and antidiabetic therapy.
近年来，由于其生物活性化合物的生物学活性，肉桂可能对 2 型糖尿病产生有益影响的科学证据不断增加。这篇综述概述了肉桂对糖尿病临床参数的影响，并总结了肉桂对葡萄糖和脂质代谢的作用机制。搜索标准包括使用 PubMed、Medline 和 Cochrane Library 数据库进行电子搜索。纳入了 2000 年至 2022 年的英文文献参考文献。经过标题和摘要审查，符合纳入标准的全文被纳入。现有证据的结果表明，肉桂改善了血糖和血脂指标。临床试验表明，肉桂还具有抗炎作用，这可能对糖尿病有益。基于 和 研究，肉桂似乎通过胰岛素模拟作用和酶活性改善来调节组织中的葡萄糖代谢。此外，肉桂似乎可以减少肠道中胆固醇和脂肪酸的吸收。目前的文献检索显示了相当数量的糖尿病患者研究。在比较已发表数据时，应强调一些局限性，包括肉桂剂量、提取物和种类、给药形式和抗糖尿病治疗的变异性。
